Journal Article

Autofluorescence for the diagnosis of visceral pleural invasion in non-small-cell lung cancer

Hiromitsu Takizawa, Kazuya Kondo, Naoya Kawakita, Mitsuhiro Tsuboi, Hiroaki Toba, Koichiro Kajiura, Yukikiyo Kawakami, Shoji Sakiyama, Akira Tangoku, Atsushi Morishita, Yasushi Nakagawa and Toshiyuki Hirose

in European Journal of Cardio-Thoracic Surgery

Published on behalf of European Association for Cardio-Thoracic Surgery

Volume 53, issue 5, pages 987-992
Published in print May 2018 | ISSN: 1010-7940
Published online December 2017 | e-ISSN: 1873-734X | DOI: https://dx.doi.org/10.1093/ejcts/ezx419
Autofluorescence for the diagnosis of visceral pleural invasion in non-small-cell lung cancer

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Show all results sharing these subjects:

  • Medical Oncology
  • Respiratory Medicine and Pulmonology
  • Surgical Oncology
  • Anatomy

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Abstract

OBJECTIVES

This study was conducted to evaluate the accuracy of autofluorescence as a mode of diagnosis for visceral pleural invasion of non-small-cell lung cancer compared with white-light by means of clinical questions to several thoracic surgeons.

METHODS

Eight independent thoracic surgeons evaluated visceral pleural invasion in 25 cases of non-small-cell lung cancer attached to the visceral pleura on lung windows of preoperative computed tomography images. At the first study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using conventional white-light images, the surgeons diagnosed visceral pleural invasion based on information in preoperative computed tomography images, histological types and videos recorded with white-light mode using a thoracoscope. At the second study meeting to evaluate the accuracy of visceral pleural invasion diagnosis using autofluorescence, the same surgeons diagnosed visceral pleural invasion based on information in 2 videos recorded in white-light mode and in autofluorescence mode using the thoracoscope.

RESULTS

The overall average sensitivity, specificity and accuracy of visceral pleural invasion diagnosis by white-light versus autofluorescence mode were 64.6% vs 83.3%, 53.9% vs 73.7% and 56.5% vs 76.0%, respectively.

CONCLUSIONS

The sensitivity, specificity and accuracy of visceral pleural invasion diagnosis was improved through the additional use of the autofluorescence mode compared with the white-light mode alone.

Keywords: Visceral pleural invasion; Non-small-cell lung cancer; Autofluorescence

Journal Article.  3285 words.  Illustrated.

Subjects: Medical Oncology ; Respiratory Medicine and Pulmonology ; Surgical Oncology ; Anatomy

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