Journal Article

MUC-1 glycosylation in endometrium: possible roles of the apical glycocalyx at implantation

John D. Aplin

in Human Reproduction

Published on behalf of European Society of Human Reproduction and Embryology

Volume 14, issue suppl_2, pages 17-25
Published in print December 1999 | ISSN: 0268-1161
Published online December 1999 | e-ISSN: 1460-2350 | DOI: https://dx.doi.org/10.1093/humrep/14.suppl_2.17
MUC-1 glycosylation in endometrium: possible roles of the apical glycocalyx at implantation

Show Summary Details

Preview

MUC-1 is a major epithelial apical surface glycoprotein in human endometrium. It has a large, extended and highly glycosylated ectodomain that contains keratan sulphate chains. MUC-1 is abundant at the luminal epithelial surface in the receptive phase, but keratan sulphate disappears at this time. MUC-1 has been shown experimentally to inhibit cell–cell interactions by steric hindrance of binding interactions mediated by receptors, including integrins and cadherins, so its high abundance at the time of implantation is unexpected. Here, various models for MUC-1 function in implantation are considered and its expression in different species compared. The possible evolutionary advantages of a maternal ‘barrier’ to implantation are discussed.

Keywords: glycosylation; implantation; keratan sulphate; mucin; MUC-1

Journal Article.  0 words. 

Subjects: Reproductive Medicine

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.