Journal Article

Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis

Shuhei Hosomi, Kenji Watanabe, Yu Nishida, Hirokazu Yamagami, Tomomi Yukawa, Koji Otani, Yasuaki Nagami, Fumio Tanaka, Koichi Taira, Noriko Kamata, Tetsuya Tanigawa, Masatsugu Shiba, Toshio Watanabe, Hisashi Nagahara, Kiyoshi Maeda and Yasuhiro Fujiwara

in Inflammatory Bowel Diseases

Volume 24, issue 6, pages 1307-1315
Published in print May 2018 | ISSN: 1078-0998
Published online April 2018 | e-ISSN: 1536-4844 | DOI: https://dx.doi.org/10.1093/ibd/izy005
Combined Infection of Human Herpes Viruses: A Risk Factor for Subsequent Colectomy in Ulcerative Colitis

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  • Gastro-intestinal and Colorectal Surgery

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Abstract

Background

Little is known about the prevalence and pathogenicity of human herpes viruses except for cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of human herpes viruses on colonic mucosa in patients with IBD and assess the long-term outcomes in these patients.

Methods

We examined the colonic mucosal specimens from 66 patients with ulcerative colitis (UC), 54 patients with Crohn’s disease (CD), and 29 healthy patients to identify the 6 most common types of human herpes virus, using multiplex polymerase chain reaction (PCR) technique.

Results

Herpes simplex virus (HSV)-1/2 and varicella-zoster virus (VZV) were not detected in any of the groups. There was a higher prevalence of Epstein-Barr virus (EBV) (21.2%) and CMV (15.1%) in patients with UC than in patients with CD (EBV 9.3%, CMV 0%) and patents in the healthy control group (EBV 0%, CMV 3.4%). The prevalence of human herpes virus (HHV)-6A/B and HHV-7 was not statistically different among the groups. Five UC patients with inflammation had coexisting CMV and EBV or HHV-6. The combined infection of CMV with EBV or HHV-6 was a significant and independent prognostic factor for subsequent colectomy in patients with UC.

Conclusions

The increased prevalence of CMV coexisting with EBV/HHV-6 infection was associated with the clinical course in patients with UC.

10.1093/ibd/izy005_video1 izy005_Video_1 5786489376001

Keywords: Crohn’s disease; cytomegalovirus; Epstein-Barr virus; human herpes virus; human herpes virus-6; ulcerative colitis

Journal Article.  5829 words.  Illustrated.

Subjects: Medicine and Health ; Clinical Medicine ; Gastroenterology ; Patient Education and Information ; Gastro-intestinal and Colorectal Surgery

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