Journal Article

GB Virus C/Hepatitis G Virus Infection in Southern China

Rong-Rong Wu, Masashi Mizokami, Kun Cao, Tatsunori Nakano, Xian-Min Ge, Su-Seng Wang, Etsuro Orito, Ken-ichi Ohba, Motokazu Mukaide, Kazumasa Hikiji, Johnson Y. N. Lau and Shiro Iino

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 175, issue 1, pages 168-171
Published in print January 1997 | ISSN: 0022-1899
Published online January 1997 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1093/infdis/175.1.168
GB Virus C/Hepatitis G Virus Infection in Southern China

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The prevalence of GB virus C/hepatitis G virus (GBV-C/HGV) infection among intravenous drug users (IVDUs), patients with liver diseases, and blood donors in Nanning, southern China was studied. GBV-C/HGV RNA was detected by reverse transcription polymerase chain reaction with primers derived from the 5'-untranslated region. GBV-C/HGV RNA was detected in 64 of 85 IVnDs, 20 of 80 persons with liver disease, and 1 of 50 blood donors. Among IVDUs, GBV-C/HGV infection was associated with antibodies to hepatis C virus (HCV) and with hepatitis B surface antigen (HBsAg). Eleven nucleotide sequences were determined and analyzed by molecular evolutionary analysis. In a phylogenetic tree, the isolates were grouped in three clusters with GBV-C and HGV grouped in two clusters. These data indicate that GBV-C/HGV infection is common in China among IVDUs but uncommon among persons with liver disease without HBsAg or anti-HCV and that there is a new group of GBV-C/HGV.

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Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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