Journal Article

Sensitive Tenofovir Resistance Screening of HIV-1 From the Genital and Blood Compartments of Women With Breakthrough Infections in the CAPRISA 004 Tenofovir Gel Trial

Xierong Wei, Gillian Hunt, Salim S. Abdool Karim, Vivek Naranbhai, Sengeziwe Sibeko, Quarraisha Abdool Karim, Jin-fen Li, Angela D. M. Kashuba, Lise Werner, Jo-Ann S. Passmore, Lynn Morris, Walid Heneine and Jeffrey A. Johnson

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 209, issue 12, pages 1916-1920
Published in print June 2014 | ISSN: 0022-1899
Published online January 2014 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1093/infdis/jiu026
Sensitive Tenofovir Resistance Screening of HIV-1 From the Genital and Blood Compartments of Women With Breakthrough Infections in the CAPRISA 004 Tenofovir Gel Trial

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The Centre for the AIDS Programme of Research in South Africa 004 (CAPRISA 004) study demonstrated that vaginally applied tenofovir gel is a promising intervention for protecting women from sexually acquiring human immunodeficiency virus (HIV). However, the potential for emergence of tenofovir resistance remains a concern in women who seroconvert while using the gel despite the lack of plasma virus resistance as assessed by population sequencing during the trial. We applied highly sensitive polymerase chain reaction–based assays to screen for tenofovir resistance in plasma and vaginal swab specimens. The absence of mutation detection suggested little immediate risk of tenofovir-resistant HIV-1 emergence and forward transmission in settings in which gel users are closely monitored for HIV seroconversion.

Keywords: Vaginal microbicide; HIV prevention; pre-exposure prophylaxis; tenofovir gel; topical PrEP

Journal Article.  3310 words. 

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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