Journal Article

SFTS Virus Infection in Nonhuman Primates

Cong Jin, Hong Jiang, Mifang Liang, Ying Han, Wen Gu, Fushun Zhang, Hua Zhu, Wei Wu, Ting Chen, Chuan Li, Weilun Zhang, Quanfu Zhang, Jing Qu, Qiang Wei, Chuan Qin and Dexin Li

in The Journal of Infectious Diseases

Published on behalf of Infectious Diseases Society of America

Volume 211, issue 6, pages 915-925
Published in print March 2015 | ISSN: 0022-1899
Published online October 2014 | e-ISSN: 1537-6613 | DOI: https://dx.doi.org/10.1093/infdis/jiu564
SFTS Virus Infection in Nonhuman Primates

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SFTS virus (SFTSV) is a highly pathogenic bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease in China. Laboratory mice have been reported to be susceptible to SFTSV infection, but the infection in nonhuman primates has not been investigated. This study is the first to report that, in rhesus macaques, SFTSV does not cause severe symptoms or death but causes fever, thrombocytopenia, leukocytopenia, and increased levels of transaminases and myocardial enzymes in blood. Viremia, virus-specific immunoglobulin M and immunoglobulin G antibodies, and neutralizing antibodies were identified in all infected macaques. Levels of the cytokines interferon γ, eotaxin, tumor necrosis factor α, and macrophage inflammatory protein 1β were significantly elevated in the blood. Minor pathological lesions were observed in the liver and kidney during the late stages of infection. Overall, SFTSV infection in rhesus macaques resembled mild SFTS in humans.

Keywords: SFTS virus; infectious animal model; nonhuman primate; pathogenesis

Journal Article.  5314 words.  Illustrated.

Subjects: Infectious Diseases ; Immunology ; Public Health and Epidemiology ; Microbiology

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