Journal Article

Regulation of in vitro and in vivo T cell activation by CD43.

E C Thurman, J Walker, S Jayaraman, N Manjunath, B Ardman and J M Green

in International Immunology

Published on behalf of Japanese Society for Immunology

Volume 10, issue 5, pages 691-701
Published in print May 1998 | ISSN: 0953-8178
Published online May 1998 | e-ISSN: 1460-2377 | DOI: https://dx.doi.org/10.1093/intimm/10.5.691
Regulation of in vitro and in vivo T cell activation by CD43.

More Like This

Show all results sharing these subjects:

  • Immunology
  • Biological Sciences

GO

Show Summary Details

Preview

Accessory molecule interactions can be critical in determining the outcome of a T cell's encounter with antigen. Cell adhesion proteins may augment T cell responses by facilitating TCR engagement of the antigen-MHC complex, while co-stimulatory molecules may deliver distinct signals that modulate T cell responsiveness. CD43 (leukosialin, sialophorin) has been suggested to influence cell activation by steric hindrance based upon the large size and glycosylation of the protein, as well as the relative abundance of the protein on the cell surface. In this paper we examine both in vitro and in vivo T cell-dependent responses in CD43-deficient mice. We demonstrate that T cells from CD43-deficient mice are hyper-responsive following both in vivo and in vitro activation, and that this is observed in response to not only TCR-CD3-mediated stimulation, but also following receptor-independent activation. This data suggests that mechanisms other than non-specific steric hindrance are important in the regulation of T cell activation by CD43.

Journal Article.  0 words. 

Subjects: Immunology ; Biological Sciences

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or purchase to access all content.