Journal Article

Changing needs of community-acquired pneumonia

Julio Alberto Ramirez and Antonio R. Anzueto

in Journal of Antimicrobial Chemotherapy

Published on behalf of British Society for Antimicrobial Chemotherapy

Volume 66, issue suppl_3, pages iii3-iii9
Published in print April 2011 | ISSN: 0305-7453
Published online April 2011 | e-ISSN: 1460-2091 | DOI: https://dx.doi.org/10.1093/jac/dkr094
Changing needs of community-acquired pneumonia

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  • Medical Oncology
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Community-acquired pneumonia (CAP) is a serious condition associated with significant morbidity and potential long-term mortality. Although the majority of patients with CAP are treated as outpatients, the greatest proportion of pneumonia-related mortality and healthcare expenditure occurs among the patients who are hospitalized. There has been considerable interest in determining risk factors and severity criteria assessments to assist with site-of-care decisions. For both inpatients and outpatients, the most common pathogens associated with CAP include Streptococcus pneumoniae, Haemophilus influenzae, group A streptococci and Moraxella catarrhalis. Atypical pathogens, Gram-negative bacilli, methicillin-resistant Staphylococcus aureus (MRSA) and viruses are also recognized aetiological agents of CAP. Despite the availability of antimicrobial therapies, the recent emergence of drug-resistant pneumococcal and staphylococcal isolates has limited the effectiveness of currently available agents. Because early and rapid initiation of empirical antimicrobial treatment is critical for achieving a favourable outcome in CAP, newer agents with activity against drug-resistant strains of S. pneumoniae and MRSA are needed for the management of patients with CAP.

Keywords: antimicrobial therapy; PSI/CURB-65 score; clinical outcomes

Journal Article.  4464 words.  Illustrated.

Subjects: Medical Oncology ; Critical Care

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