Journal Article

Prognostic Significance of X-ray Cross-complementing Group 1 T-77C Polymorphism in Resected Non-small Cell Lung Cancer

Wei-Chung Hsieh, Ya-Wen Cheng, Cuei-Jyuan Lin, Ming-Chih Chou, Chih-Yi Chen and Huei Lee

in Japanese Journal of Clinical Oncology

Volume 39, issue 2, pages 81-85
Published in print February 2009 | ISSN: 0368-2811
Published online December 2008 | e-ISSN: 1465-3621 | DOI: https://dx.doi.org/10.1093/jjco/hyn130
Prognostic Significance of X-ray Cross-complementing Group 1 T-77C Polymorphism in Resected Non-small Cell Lung Cancer

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Objective

A novel T-77C polymorphism in the promoter region of the DNA repair gene X-ray cross-complementing group 1 (XRCC1) may modulate its transcription to increase the risk of lung cancer. Here, we attempt to clarify: (i) whether the XRCC1 T-77C polymorphism was associated with lung cancer risk in Taiwanese and (ii) whether this polymorphism could act as a prognostic indicator to predict the clinical outcome of non-small-cell lung cancer (NSCLC) patients.

Methods

A total of 294 primary lung cancer patients and 288 potential controls were recruited into our study. Clinical data were collected. The genotypes of XRCC1 T-77C were identified by polymerase chain reaction.

Results

Our case–control study showed that the XRCC1 T-77C polymorphism was not associated with the risk of lung cancer in Taiwanese patients. To verify the impact of the XRCC1 T-77C polymorphism on the clinical outcome of NSCLC, survival analysis showed that patients with TT had a lower survival rate than those with the TC + CC genotype (33.1% versus 48.8%, P = 0.031). The Cox regression analysis further indicated that patients with the TT genotype had a 1.84-fold risk compared with those with the TC + CC genotype (95% CI, 1.16–2.86, P = 0.008).

Conclusion

Our results suggest that XRCC1 T-77C variants (TC + CC) may act as a favorable prognostic indicator of resected NSCLC.

Keywords: XRCC1 genetic polymorphism; NSCLC; prognosis

Journal Article.  3027 words.  Illustrated.

Subjects: Medical Oncology

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