Journal Article

Adjuvant Chemotherapy in Patients with Completely Resected Small Cell Lung Cancer: A Retrospective Analysis of 26 Consecutive Cases

Hidenori Mizugaki, Yutaka Fujiwara, Noboru Yamamoto, Shigehiro Yagishita, Satoru Kitazono, Ayako Tanaka, Hidehito Horinouchi, Shintaro Kanda, Hiroshi Nokihara, Koji Tsuta, Hisao Asamura and Tomohide Tamura

in Japanese Journal of Clinical Oncology

Volume 44, issue 9, pages 835-840
Published in print September 2014 | ISSN: 0368-2811
Published online August 2014 | e-ISSN: 1465-3621 | DOI: https://dx.doi.org/10.1093/jjco/hyu092
Adjuvant Chemotherapy in Patients with Completely Resected Small Cell Lung Cancer: A Retrospective Analysis of 26 Consecutive Cases

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  • Clinical Medicine
  • Medical Oncology
  • Radiation Oncology
  • Surgical Oncology

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Objective

Several clinical studies have demonstrated the efficacy and safety of adjuvant chemotherapy in patients with completely resected small cell lung cancer for a selected limited stage. However, it is unclear whether adjuvant chemotherapy is feasible in clinical practice. The objective of this study was to analyze the efficacy and safety of adjuvant chemotherapy for small cell lung cancer patients retrospectively in clinical practice.

Methods

From January 2002 to March 2012, 56 small cell lung cancer patients underwent surgery as initial therapy in our institute. Of these, 26 patients received adjuvant chemotherapy. The clinical data of patients who received adjuvant chemotherapy were retrospectively analyzed.

Results

The chemotherapy regimens were cisplatin and irinotecan in 16 patients, cisplatin and etoposide in 1 and carboplatin and etoposide in 9. Median follow-up time was 44.8 months. Nineteen (73%) patients received the full course of chemotherapy. Median recurrence-free survival was 21.4 months. Median survival time was not reached. There was no treatment-related death.

Conclusion

Adjuvant chemotherapy may be generally safe and efficacious in selected small cell lung cancer patients.

Keywords: small cell lung cancer; surgery; adjuvant chemotherapy

Journal Article.  2536 words.  Illustrated.

Subjects: Clinical Medicine ; Medical Oncology ; Radiation Oncology ; Surgical Oncology

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