Journal Article

General Health Status and Late Effects Among Adolescent and Young Adult Survivors of Childhood Cancer in Japan

Shuichi Ozono, Yasushi Ishida, Misato Honda, Jun Okamura, Keiko Asami, Naoko Maeda, Naoko Sakamoto, Hiroko Inada, Tsuyako Iwai, Kiyoko Kamibeppu, Naoko Kakee and Keizo Horibe

in Japanese Journal of Clinical Oncology

Volume 44, issue 10, pages 932-940
Published in print October 2014 | ISSN: 0368-2811
Published online August 2014 | e-ISSN: 1465-3621 | DOI: https://dx.doi.org/10.1093/jjco/hyu102
General Health Status and Late Effects Among Adolescent and Young Adult Survivors of Childhood Cancer in Japan

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  • Clinical Medicine
  • Medical Oncology
  • Radiation Oncology
  • Surgical Oncology

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Objective

We sought to investigate general health status and late effects among adolescent and young adult survivors of childhood cancer.

Methods

We conducted a cross-sectional survey, using self-rated questionnaires on current and past health problems. Questionnaires were provided to childhood cancer survivors, a comparison group of siblings and a general population control group that was recruited online. χ2 tests were used to compare responses to the 72 survey items.

Results

The final sample included 185 childhood cancer survivors (72% response rate), 72 siblings and 1000 general population controls. In the childhood cancer survivors group, the median age of diagnosis was 8 years and the median age at survey was 23 years. According to the physicians' reports, 56% of the childhood cancer survivors experienced at least one late effect. In descending order of prevalence, the current symptoms in the childhood cancer survivors group were (i) impaired visual acuity (45%), (ii) dizziness (36%) and (iii) any allergy (34%). The three most common symptoms had similar prevalence rates in each of the groups. As compared with the control group, the following physical symptoms were significantly more common in the childhood cancer survivors group: mental retardation (odds ratio: 48.6, P < 0.01); cataract (odds ratio: 29.7); suspected infertility (odds ratio: 25.1); delayed puberty (odds ratio 24.9); growth hormone deficiency (odds ratio: 23.0); and other audiovisual, urinary, endocrine, infertility, cardiovascular, respiratory, gastrointestinal, spinal, extremity and neuromuscular problems.

Conclusions

Many adolescent/young adult childhood cancer survivors could be suffering from ongoing late effects that stem from cancer and its treatment. Overall health monitoring for childhood cancer survivors can provide indispensable benefits.

Keywords: childhood cancer survivors; late effects; general health status

Journal Article.  5342 words.  Illustrated.

Subjects: Clinical Medicine ; Medical Oncology ; Radiation Oncology ; Surgical Oncology

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