Journal Article

Platinum hypersensitivity and desensitization

Shingo Miyamoto, Rika Okada and Kazumichi Ando

in Japanese Journal of Clinical Oncology

Volume 45, issue 9, pages 795-804
Published in print September 2015 | ISSN: 0368-2811
Published online June 2015 | e-ISSN: 1465-3621 | DOI: https://dx.doi.org/10.1093/jjco/hyv081
Platinum hypersensitivity and desensitization

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Platinum agents are drugs used for various types of cancer. With increased frequency of administration of platinum agents, hypersensitivity reactions appear more frequently, occurring in over 25% of cases from the seventh cycle or second line onward. It then becomes difficult to conduct treatment using these agents. Various approaches have been investigated to address hypersensitivity reactions to platinum agents. Desensitization, which gradually increases the concentration of the anticancer drug considered to be the antigen until the target dosage, has been reported as being particularly effective, with a success rate of 80–100%. The aims of this paper are to present the current findings regarding hypersensitivity reactions to platinum agents and to discuss attempts of using desensitization against hypersensitivity reactions worldwide.

Keywords: platinum; hypersensitivity; desensitization

Journal Article.  7465 words. 

Subjects: Medical Oncology

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