Journal Article

Biological markers of invasive breast cancer

Akiko Matsumoto, Hiromitsu Jinno, Tomofumi Ando, Taku Fujii, Tetsuya Nakamura, Junichi Saito, Maiko Takahashi, Tetsu Hayashida and Yuko Kitagawa

in Japanese Journal of Clinical Oncology

Volume 46, issue 2, pages 99-105
Published in print February 2016 | ISSN: 0368-2811
Published online October 2015 | e-ISSN: 1465-3621 | DOI: https://dx.doi.org/10.1093/jjco/hyv153
Biological markers of invasive breast cancer

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  • Radiation Oncology
  • Surgical Oncology

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Biological markers for breast cancer are biomolecules that result from cancer-related processes and are associated with particular clinical outcomes; they thus help predict responses to therapy. In recent years, gene expression profiling has made the molecular classification of breast cancer possible. Classification of breast cancer by immunohistochemical expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 and Ki-67 is standard practice for clinical decision-making. Assessments of hormone receptor expression and human epidermal growth factor receptor 2 overexpression help estimate benefits from targeted therapies and have greatly improved prognoses for women with these breast cancer types. Although Ki-67 positivity is associated with an adverse outcome, its clear identification is an aid to optimal disease management. Standardization of testing methodology to minimize inter-laboratory measurement variations is a remaining issue. Multi-gene assays provide prognostic information and identify those most likely to benefit from systemic chemotherapy. Incorporating molecular profiles with conventional pathological classification would be more precise, and could enhance the clinical development of personalized therapy in breast cancer.

Keywords: biomarkers; estrogen receptor; progesterone receptor; HER2; Ki-67

Journal Article.  6719 words. 

Subjects: Clinical Medicine ; Medical Oncology ; Radiation Oncology ; Surgical Oncology

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