Book

Chasing Pain: The Search for a Neurobiological Mechanism

Kenneth L. Casey

Published on behalf of Oxford University Press

Published in print February 2019 | ISBN: 9780190880231
Published online February 2019 | e-ISBN: 9780190880248 | DOI: https://dx.doi.org/10.1093/med/9780190880231.001.0001
Chasing Pain: The Search for a Neurobiological Mechanism

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By several measures, no human experience is more important than pain. Chasing Pain discusses the evolution of scientific and clinical evidence that supports contemporary concepts of how pain is created by the nervous system. These concepts influence medical practice, neuroscientific research, and philosophical ideas about pain and other neurological functions. Historically, pain has been conceived as emerging either from an undefined pattern of neural activity or from anatomically localized and physiologically unique structures in the nervous system. Research during the early and middle 20th century showed that pain normally requires both sensory detectors of noxious events (nociceptors) and brain mechanisms that generate emotional experience. Realistic models of pain neurobiology must also consider that the normally tight link between pain and tissue damage is strongly affected by several neurological diseases, emotionally compelling circumstances, complex cognitive processes, and pain itself. As one example of physiological pain modulation, readers may access the author’s videos of surgery performed with acupuncture as the sole analgesic method. Chasing Pain reviews the neuroscientific research and clinical experience that has, over time, greatly enriched our understanding of pain neurobiology, guided medical practice, and influenced contemporary concepts of neurological functions. The limitations of our current conceptual models of pain are exemplified by considering several common, clinically challenging conditions that remain very poorly understood.

Book.  192 pages.  Illustrated.

Subjects: Pain Medicine ; Anaesthetics ; Surgery

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Table of Contents

Introduction in Chasing Pain: The Search for a Neurobiological Mechanism

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A Sample at the Extremes in Chasing Pain: The Search for a Neurobiological Mechanism

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Drivers of Pain Research and a Meeting in Issaquah in Chasing Pain: The Search for a Neurobiological Mechanism

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Functional Localization, the Spinothalamic Tract, and Neurosurgery for Pain in Chasing Pain: The Search for a Neurobiological Mechanism

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Emotions, Affect, and the Limbic System in Chasing Pain: The Search for a Neurobiological Mechanism

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Early Evidence of Central Nervous System Control and a Conceptual Model Revisited in Chasing Pain: The Search for a Neurobiological Mechanism

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Psychophysics and Nociceptors in Chasing Pain: The Search for a Neurobiological Mechanism

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Central Sensitization and Pain Genes in Chasing Pain: The Search for a Neurobiological Mechanism

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Central Nervous System Modulation of Pain in Chasing Pain: The Search for a Neurobiological Mechanism

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Central Nervous System Generation and Modulation of Pain in Chasing Pain: The Search for a Neurobiological Mechanism

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