Chapter

Biologic and Regenerative Therapies

Ian Dworkin, Daniel A. Fung and Timothy T. Davis

in The Spine Handbook

Published on behalf of Oxford University Press

Published in print May 2018 | ISBN: 9780199350940
Published online June 2018 | e-ISBN: 9780199390793 | DOI: https://dx.doi.org/10.1093/med/9780199350940.003.0027
Biologic and Regenerative Therapies

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  • Pain Medicine
  • Rehabilitation Medicine
  • Spinal Surgery

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Low back pain is one of the most debilitating conditions worldwide, and a major cause is degenerative disc disease. Current therapies range from conservative treatments, such as medications, physical therapy, and other modalities, to more invasive treatments such as injections and surgery; however, these therapies neither stop the progression of degeneration nor restore function to the degenerating disc; they focus on symptom management, not on etiology. A novel approach to treating degenerative disc disease involves using regenerative therapies such as stem cells, growth factors, and gene therapy. The goal of these therapies is not just to decrease symptoms, but to reverse disc degeneration, while simultaneously enhancing current treatment modalities. Though clinical translation of regenerative therapies is in its infancy, in vitro and in vivo investigations have revealed these therapies’ potential in treating degenerative disc disease as well as a multitude of other musculoskeletal conditions.

Chapter.  9223 words.  Illustrated.

Subjects: Pain Medicine ; Rehabilitation Medicine ; Spinal Surgery

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