Chapter

Neurobiology of depression

Roger S. McIntyre and Jay Nathanson

in Severe Depression

Published on behalf of Oxford University Press

Published in print February 2010 | ISBN: 9780199570249
Published online May 2011 | e-ISBN: 9780191740350 | DOI: https://dx.doi.org/10.1093/med/9780199570249.003.0006

Series: Oxford Psychiatry Library

Neurobiology of depression

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There are three major networks associated with the pathophysiology (and possibly treatment) of MDD: the immunoinflammatory network, the metabolic network (e.g., insulin, insulin-growth factor), and the neuroendocrine network (e.g., cortisol)

Disturbances in neuroplasticity and neurotrophism are implicated as critical pathophysiological processes in MDD manifested as alterations in neurotransmitter signalling and changes in cellular resilience and survival

Exposure to environmental pathogens (e.g., proximal and psychosocial stressors) accounts for a significant proportion of the population attributable risk for MDD

Unraveling gene-environment interactions are a critical research vista for the future

Chapter.  5702 words.  Illustrated.

Subjects: Psychiatry

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