Chapter

Pharmacological approaches to depression

Roger S. McIntyre and Jay Nathanson

in Severe Depression

Published on behalf of Oxford University Press

Published in print February 2010 | ISBN: 9780199570249
Published online May 2011 | e-ISBN: 9780191740350 | DOI: https://dx.doi.org/10.1093/med/9780199570249.003.0007

Series: Oxford Psychiatry Library

Pharmacological approaches to depression

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Tricyclic antidepressants have been the conventional standard of efficacy in severe depression

Conventional pharmacotherapy (e.g., second- and later- generation antidepressants) offer efficacy in the treatment of MDD

Placebo response rates in severe depression have been consistently lower when compared to mild-moderate depression

The majority of individuals with severe depression will not achieve and/or sustain remission with antidepressant monotherapy

Chapter.  4211 words.  Illustrated.

Subjects: Psychiatry

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