Bipolar Disorder

Robert C. Young and Nahla A. Mahgoub

in Late-Life Mood Disorders

Published on behalf of Oxford University Press

Published in print February 2013 | ISBN: 9780199796816
Published online June 2013 | e-ISBN: 9780199323081 | DOI:
Bipolar Disorder

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  • Old Age Psychiatry
  • Neurology


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Older adults with bipolar (BP) disorder present a heterogeneous group of patients who have diverse clinical characteristics and comorbidities, and presumably differing pathophysiology and etiology. Age-related factors including age at onset of illness and age-associated neurobiological and psychosocial factors may contribute to these extents of heterogeneity. Relevant neurobiological changes may include vascular and degenerative processes. This chapter provides an overview of the limited evidence-base. Investigation of this subgroup of BP patients presents both challenges and important opportunities for investigation. Opportunities include studies of markers of vulnerability, of how heterogeneity may be associated with differences in outcomes and may guide development of novel treatments, and of the nature of clinical features shared with other geriatric disorders.

Chapter.  16350 words.  Illustrated.

Subjects: Old Age Psychiatry ; Neurology

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