Voltage-Sensitive Dye Imaging

William Frost and Jian-young Wu

in Basic Electrophysiological Methods

Published on behalf of Oxford University Press

Published in print February 2015 | ISBN: 9780199939800
Published online April 2015 | e-ISBN: 9780190226978 | DOI:
Voltage-Sensitive Dye Imaging

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Voltage sensitive dye imaging (VSD) can be used to record neural activity in hundreds of locations in preparations ranging from mammalian cortex to invertebrate ganglia. Because fast VSDs respond to membrane potential changes with microsecond temporal resolution, these are better suited than calcium indicators for recording rapid neural signals. Here we describe methods for using a 464- element photodiode array and fast VSDs to record signals ranging from large scale network activity in brain slices and in vivo mammalian preparations, to action potentials in over 100 individual neurons in invertebrate ganglia.

Chapter.  10970 words.  Illustrated.

Subjects: Neurology

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