Journal Article

Association of 25-OH Vitamin D Status with Findings on Screening Colonoscopy

Carl Bryce

in Military Medicine

Volume 183, issue suppl_1, pages 547-551
Published in print March 2018 | ISSN: 0026-4075
Published online April 2018 | e-ISSN: 1930-613X | DOI: https://dx.doi.org/10.1093/milmed/usx152
Association of 25-OH Vitamin D Status with Findings on Screening Colonoscopy

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  • Medicine and Health
  • Emergency Medicine
  • Trauma and Orthopaedic Surgery
  • Military Psychology
  • Warfare and Defence

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Abstract

Objectives

Greater serum levels and dietary intake of vitamin D have been inversely associated with the risk of multiple cancers including colon cancer. Most colorectal cancers are thought to arise from adenomatous polyps, which become dysplastic under the influence of numerous factors. Prospective data are needed to distinguish between association or a causative role of vitamin D in the pathogenesis of colorectal cancer.

Methods

A prospective cohort study was designed, located at a hospital-based screening colonoscopy referral center, including Department of Defense beneficiaries aged 18 yr or older. A serum 25-hydroxyvitamin D level was drawn, and colonoscopy findings were recorded. A power calculation using p = 0.8, alpha = 0.05 generated a necessary sample size of n = 224 to detect an association between vitamin D level and adenomatous polyp. Unconditional multivariable logistic regression modeling was used to evaluate associations between outcomes, adjusted for known risk factors.

Results

Of final population (n) = 228, 155 (68%) were diagnosed with vitamin D insufficiency (<30 ng/mL) and 104 (46%) were found to have adenomatous polyps. Adjusted odds ratio for adenomatous colon polyp given vitamin D <30 ng/mL = 1.16 (95% CI 0.57–2.36).

Conclusions

Serum vitamin D level was not associated with increased adenomatous polyp detection at screening colonoscopy in this population.

Keywords: 25-Hydroxy Vitamin D; colorectal adenoma; colorectal cancer; screening

Journal Article.  2947 words.  Illustrated.

Subjects: Medicine and Health ; Emergency Medicine ; Trauma and Orthopaedic Surgery ; Military Psychology ; Warfare and Defence

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