Journal Article

A Worldwide Survey of Human Male Demographic History Based on Y-SNP and Y-STR Data from the HGDP–CEPH Populations

Wentao Shi, Qasim Ayub, Mark Vermeulen, Rong-guang Shao, Sofia Zuniga, Kristiaan van der Gaag, Peter de Knijff, Manfred Kayser, Yali Xue and Chris Tyler-Smith

in Molecular Biology and Evolution

Published on behalf of Society for Molecular Biology and Evolution

Volume 27, issue 2, pages 385-393
Published in print February 2010 | ISSN: 0737-4038
Published online October 2009 | e-ISSN: 1537-1719 | DOI: https://dx.doi.org/10.1093/molbev/msp243

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We have investigated human male demographic history using 590 males from 51 populations in the Human Genome Diversity Project - Centre d’Étude du Polymorphisme Humain worldwide panel, typed with 37 Y-chromosomal Single Nucleotide Polymorphisms and 65 Y-chromosomal Short Tandem Repeats and analyzed with the program Bayesian Analysis of Trees With Internal Node Generation. The general patterns we observe show a gradient from the oldest population time to the most recent common ancestors (TMRCAs) and expansion times together with the largest effective population sizes in Africa, to the youngest times and smallest effective population sizes in the Americas. These parameters are significantly negatively correlated with distance from East Africa, and the patterns are consistent with most other studies of human variation and history. In contrast, growth rate showed a weaker correlation in the opposite direction. Y-lineage diversity and TMRCA also decrease with distance from East Africa, supporting a model of expansion with serial founder events starting from this source. A number of individual populations diverge from these general patterns, including previously documented examples such as recent expansions of the Yoruba in Africa, Basques in Europe, and Yakut in Northern Asia. However, some unexpected demographic histories were also found, including low growth rates in the Hazara and Kalash from Pakistan and recent expansion of the Mozabites in North Africa.

Keywords: Y-STR; Y-SNP; HGDP–CEPH; male demographic history; BATWING; serial founder model

Journal Article.  5219 words.  Illustrated.

Subjects: Evolutionary Biology ; Molecular and Cell Biology

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