Journal Article

The interaction of 2-phenylbenzimidazole compounds with DNA: The influence of terminal substituents

Yukio Kubota, Seiji Tani and Junichi Nakamura

in Nucleic Acids Symposium Series

Volume 2, issue 1, pages 193-194
Published in print November 2002 | ISSN: 0261-3166
Published online November 2002 | e-ISSN: 1746-8272 | DOI: https://dx.doi.org/10.1093/nass/2.1.193
The interaction of 2-phenylbenzimidazole compounds with DNA: The influence of terminal substituents

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We have studied the influence of terminal substituents, amidinium group and N-methylpiperazine ring, of 2-phenylbenzimidazole compounds (1–6; Figure 1) on their DNA-binding modes. Experimental results reveal that 1–3 are accepted in intercalation pockets owing to structural flexibility of the N-methylpiperazine ring, while 4–6 bind to the groove of DNA because of steric hindrance between the flmirtminm group and the DNA phosphate-sugar backbone.

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Subjects: Chemistry ; Bioinformatics and Computational Biology ; Genetics and Genomics ; Molecular and Cell Biology

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