Journal Article

Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes

John Varlotto, Christopher DiMaio, Clemens Grassberger, Matthew Tangel, Heath Mackley, Matt Pavelic, Charles Specht, Steven Sogge, Dan Nguyen, Michael Glantz, Cheng Saw, Urvashi Upadhyay, Richard Moser, Shakeeb Yunus, Paul Rava, Thomas Fitzgerald, Jonathan Glanzman and Jonas Sheehan

in Neuro-Oncology Practice

Published on behalf of The Society for Neuro-Oncology

Volume 3, issue 3, pages 173-187
Published in print September 2016 | ISSN: 2054-2577
Published online August 2015 | e-ISSN: 2054-2585 | DOI: https://dx.doi.org/10.1093/nop/npv029
Multi-modality management of craniopharyngioma: a review of various treatments and their outcomes

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  • Medical Oncology
  • Palliative Medicine
  • Radiation Oncology
  • Clinical Radiology
  • Neurosurgery

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Craniopharyngioma is a rare tumor that is expected to occur in ∼400 patients/year in the United States. While surgical resection is considered to be the primary treatment when a patient presents with a craniopharyngioma, only 30% of such tumors present in locations that permit complete resection. Radiotherapy has been used as both primary and adjuvant therapy in the treatment of craniopharyngiomas for over 50 years. Modern radiotherapeutic techniques, via the use of CT-based treatment planning and MRI fusion, have permitted tighter treatment volumes that allow for better tumor control while limiting complications. Modern radiotherapeutic series have shown high control rates with lower doses than traditionally used in the two-dimensional treatment era. Intracavitary radiotherapy with radio-isotopes and stereotactic radiosurgery may have a role in the treatment of recurrent cystic and solid recurrences, respectively. Recently, due to the exclusive expression of the Beta-catenin clonal mutations and the exclusive expression of BRAF V600E clonal mutations in the overwhelming majority of adamantinomatous and papillary tumors respectively, it is felt that inhibitors of each pathway may play a role in the future treatment of these rare tumors.

Keywords: craniopharyngioma; proton therapy; radiosurgery; review; surgery

Journal Article.  8835 words.  Illustrated.

Subjects: Medical Oncology ; Palliative Medicine ; Radiation Oncology ; Clinical Radiology ; Neurosurgery

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