Journal Article

Anaplastic astrocytoma and non-1p/19q co-deleted anaplastic oligoastrocytoma: long-term survival, employment, and performance status of survivors

Elena I. Pentsova, Anne S. Reiner, Katherine S. Panageas and Lisa M. DeAngelis

in Neuro-Oncology Practice

Published on behalf of The Society for Neuro-Oncology

Volume 3, issue 2, pages 71-76
Published in print June 2016 | ISSN: 2054-2577
Published online October 2015 | e-ISSN: 2054-2585 | DOI: https://dx.doi.org/10.1093/nop/npv043
Anaplastic astrocytoma and non-1p/19q co-deleted anaplastic oligoastrocytoma: long-term survival, employment, and performance status of survivors

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  • Medical Oncology
  • Palliative Medicine
  • Radiation Oncology
  • Clinical Radiology
  • Neurosurgery

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Background

Despite optimal treatment for patients with anaplastic gliomas, median survival is 2 to 5 years, but some young adults survive longer. We sought to evaluate the functional and employment status of long-term survivors (5 years or more) diagnosed with anaplastic astrocytoma or non-1p/19q co-deleted anaplastic oligoastrocytoma.

Methods

We retrospectively identified patients with a diagnosis of anaplastic glioma at Memorial Sloan Kettering Cancer Center from 1999 to 2005. We reviewed demographics, pathology, 1p/19q status, survival, and treatment. Overall survival was estimated by the Kaplan-Meier method.

Results

There were 195 patients; 167 with anaplastic astrocytoma and 28 with anaplastic oligoastrocytoma. All patients were observed either to death or last follow-up. Sixty-four patients (33%) were identified as long-term survivors; 58% of these were men. The median age of the long-term survivors was 39 years and the median Karnofsky Performance Score was 100 at diagnosis. Thirteen patients underwent stereotactic biopsy, 7 had a gross total resection, and 44 a subtotal resection. Fifty-four patients completed radiation therapy as initial treatment; 54 received chemotherapy. Five years following diagnosis, median KPS was 90 and 55% of long-term survivors were employed and remained fully functional.

Conclusions

One-third of patients with non-co-deleted anaplastic glioma were long-term survivors, and more than one-half of long-term survivors resumed their prior level of employment and activity. However, a significant proportion could not return to normal function. These findings have serious implications for the social and financial status of these predominantly young adult survivors.

Keywords: Anaplastic astrocytoma; anaplastic oligoastrocytoma; employment

Journal Article.  3823 words.  Illustrated.

Subjects: Medical Oncology ; Palliative Medicine ; Radiation Oncology ; Clinical Radiology ; Neurosurgery

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