genomic library

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A collection of cloned DNA fragments representing all the nucleotide sequences in the genome (q.v.) of an organism. A genomic library is usually constructed by cutting genomic DNA into random fragments, ligating the resulting fragments into a suitable cloning vector, and transforming a host cell. The library can then be screened with a molecular probe (q.v.) to identify a clone of interest, or used for sequence analysis. Compare with cDNA library. See Chronology, 1978, Maniatis et al.; bacterial artificial chromosomes (BACs), cosmid, DNA vector, lambda phage vector, plasmid cloning vector, P1 artificial chromosomes (PACs), restriction endonuclease, transformation, yeast artificial chromosomes (YACs).

Subjects: Chemistry — Genetics and Genomics.

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