Book

Genes, brain, and emotions

Edited by Andrei C. Miu, Judith R. Homberg and Klaus-Peter Lesch

Published in print April 2019 | ISBN: 9780198793014
Published online June 2019 | e-ISBN: 9780191834745 | DOI: https://dx.doi.org/10.1093/oso/9780198793014.001.0001

Series: Series in Affective Science

Genes, brain, and emotions

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  • Development of the Nervous System
  • Disorders of the Nervous System

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With the advent of methods from behavioral genetics, molecular biology, and cognitive neuroscience, affective science has recently started to approach genetic influences on emotion, and the underlying intermediate neural mechanisms through which genes and experience shape emotion. The aim of this volume is to offer a comprehensive account of current research in the genetics of emotion, written by leading researchers, with extensive sections focused on methods, intermediate phenotypes, and clinical and translational work. Major methodological approaches are reviewed in the first section, including the two traditional “workhorses” in the field, twin studies and gene–environment interaction studies, and the more recently developed epigenetic modification assays, genome-wide association studies, and optogenetic methods. Parts 2 and 3 focus on a variety of psychological (e.g. fear conditioning, emotional action control, emotion regulation, emotional memory, decision-making) and biological (e.g. neural activity assessed using functional neuroimaging, electroencephalography, and psychophysiological methods; telomere length) mechanisms, respectively, that may be viewed as intermediate phenotypes in the pathways between genes and emotional experience. Part 4 concentrates on the genetics of emotional dysregulation in neuropsychiatric disorders (e.g. post-traumatic stress disorder, eating disorders, obsessive–compulsive disorder, Tourette’s syndrome), including factors contributing to the risk and persistence of these disorders (e.g. child maltreatment, personality, emotional resilience, impulsivity). In addition, two chapters in Part 4 review genetic influences on the response to psychotherapy (i.e. therapygenetics) and pharmacological interventions (i.e. pharmacogenetics) in anxiety and affective disorders.

Keywords: emotion; genetics; neuroscience; brain; genotype; phenotype

Book.  464 pages.  Illustrated.

Subjects: Development of the Nervous System ; Disorders of the Nervous System

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Table of Contents

Genes, brain and emotions: Introduction in Genes, brain, and emotions

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Twin studies of emotion in Genes, brain, and emotions

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Epigenetics and twin studies in Genes, brain, and emotions

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Genome-wide association studies in Genes, brain, and emotions

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Methods and theoretical approaches in Genes, brain, and emotions

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Fear learning and extinction in Genes, brain, and emotions

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Emotional action control in Genes, brain, and emotions

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