Journal Article

0125 Role Of Diet In Modulating The Effects Of Sodium Oxybate On Weight Gain In Male Sprague-dawley Rats

M M Houser, D S Scali, K A Savage, A I Zahlan, C E Perez-Leighton and J A Teske

in SLEEP

Published on behalf of American Academy of Sleep Medicine

Volume 41, issue suppl_1, pages A49-A49
ISSN: 0161-8105
Published online April 2018 | e-ISSN: 1550-9109 | DOI: https://dx.doi.org/10.1093/sleep/zsy061.124

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Abstract

Introduction

Sodium oxybate (SXB) is an FDA approved medication for the treatment of cataplexy and/or excessive daytime sleepiness for adults with narcolepsy, yet its effects on bodyweight, calorie intake and food preference are unclear. We aimed to determine the effects of SBX on bodyweight and feeding in rats under a combination of sleep disruption and unhealthy eating with a palatable cafeteria-style diet. We hypothesized that SBX would affect weight, feeding and energy expenditure in a manner dependent on diet and the presence of sleep disruption.

Methods

Male Sprague-Dawley (12-week old) rats were fed rodent chow or a cafeteria-style diet (16-d, rotating selection of 24 sweet and savory human foods plus chow ad libitum). After a 7-d acclimation period to the diet, rats either slept undisturbed or were exposed to pre-recorded environmental noise to elicit sleep disruption (8h/d during the light cycle) and received saline or SBX (i.p. once daily in the light cycle) in addition to their respective diets for 9-d. Weight gain, calorie intake, energy expenditure by indirect calorimetry and food preference (chow, sweet or savory foods) were measured.

Results

Cafeteria diet feeding significantly increased weight gain and calorie intake compared to chow, but the combination of the cafeteria diet and sleep disruption caused significantly more weight gain and calorie intake than cafeteria diet or sleep disruption alone. In rats fed chow, SBX caused weight loss and decreased total energy expenditure only in chow-fed rats that had sleep disruption. SBX significantly decreased weight gain in rats that had sleep disruption and/or fed cafeteria diet. SBX significantly decreased total calorie intake due to chow and both sweet and savory foods in all groups except in sleep disrupted rats fed cafeteria diet where SBX failed to decrease intake of preferred palatable foods (sweet).

Conclusion

SBX altered bodyweight and feeding in a manner dependent on diet and sleep disruption. Therapies to improve sleep may cause unintended weight loss or gain if diet is not considered.

Support (If Any)

Jazz Pharmaceuticals.

Journal Article.  0 words. 

Subjects: Neurology ; Sleep Medicine ; Clinical Neuroscience ; Neuroscience

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