Journal Article

Secretory proteins of Mycobacterium habana induce a protective immune response against experimental tuberculosis

Vinita Chaturvedi, Divya Jyoti, Sudhir Srivastava and Hardwar P. Gupta

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 26, issue 2, pages 143-151
Published in print November 1999 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.1999.tb01382.x
Secretory proteins of Mycobacterium habana induce a protective immune response against experimental tuberculosis

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Abstract

The capacity of proteins of Mycobacterium habana TMC 5135 secreted into culture medium during the mid-exponential growth phase (secretory proteins, SPs) to induce protective immunity against Mycobacterium tuberculosis H37Rv was studied in the mouse model. Mice immunized with SPs followed by a challenge with M. tuberculosis H37Rv showed lesser M. tuberculosis bacilli in their lung and spleen and survived longer than unimmunized controls. The findings suggest that SP antigens of M. habana are protective against tuberculosis infection.

Keywords: Secretory protein; Protection; Mycobacterium habana; Mycobacterium tuberculosis

Journal Article.  2951 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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