Journal Article

Viruses, cancer and aids

Robin A. Weiss

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 26, issue 3-4, pages 227-232
Published in print December 1999 | ISSN: 0928-8244
Published online January 2006 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.1999.tb01393.x
Viruses, cancer and aids

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Abstract

Patients with AIDS are at risk of lymphoma and Kaposi's sarcoma. These tumours are associated with the gamma herpesviruses, Epstein-Barr virus (EBV) and human herpesvirus 8 (HHV-8), although a proportion of AIDS lymphomas lacks both viruses. EBV and HHV-8 are latent in the tumour cells, with genes that play a direct role in driving cell proliferation. Human immunodeficiency virus, in contrast, while being the greatest risk factor for lymphoma and Kaposi's sarcoma, acts indirectly, mainly by causing immune suppression, as immunosuppressed transplant patients are at risk for the same types of tumour.

Keywords: Oncogenic virus; Immune deficiency; AIDS; Human herpesvirus 8

Journal Article.  2952 words. 

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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