Journal Article

Characterization of Streptococcus pneumoniae isolated from children with otitis media

Chinwendu Onwubiko, Courtney Shires, Lisa R. Quin, Edwin Swiatlo and Larry S. McDaniel

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 50, issue 1, pages 119-125
Published in print June 2007 | ISSN: 0928-8244
Published online April 2007 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.2007.00245.x
Characterization of Streptococcus pneumoniae isolated from children with otitis media

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Abstract

Streptococcus pneumoniae is the main causative agent of acute otitis media in children. Serotype-based vaccines have provided some protection against otitis media, but not as much as anticipated, demonstrating the need for alternative vaccine options. Pneumococcal otitis media isolates were obtained from children 5 years old or younger from hospitals around Mississippi in the prevaccine era (1999–2000). These isolates were compared by capsular typing, pneumococcal surface protein A (PspA) family typing, antibiotic susceptibility, and DNA fingerprinting. Our study shows that there is great genetic variability among pneumococcal clinical isolates of otitis media, except with regard to PspA. Therefore, efforts focused on the development of a PspA-based pneumococcal vaccine would be well placed.

Keywords: pneumococcus; otitis media; PspA; capsular serotypes; BOX PCR

Journal Article.  4178 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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