Journal Article

Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model

Mark T. Albrecht, Jim E. Eyles, Les W. Baillie and Andrea M. Keane-Myers

in FEMS Immunology & Medical Microbiology

Published on behalf of Federation of Microbiological Societies

Volume 65, issue 3, pages 505-509
Published in print August 2012 | ISSN: 0928-8244
Published online July 2012 | e-ISSN: 1574-695X | DOI: https://dx.doi.org/10.1111/j.1574-695X.2012.00974.x
Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model

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Abstract

The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y. pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.

Keywords: anthrax; plague; DNA vaccine

Journal Article.  2683 words.  Illustrated.

Subjects: Medical Microbiology and Virology ; Biotechnology ; Genetics and Genomics ; Microbiology ; Molecular and Cell Biology

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