Journal Article

Contribution of catalase to hydrogen peroxide resistance in <i>Enterococcus faecalis</i>

Michael Baureder, Ronny Reimann and Lars Hederstedt

in FEMS Microbiology Letters

Volume 331, issue 2, pages 160-164
Published in print June 2012 |
Published online May 2012 | e-ISSN: 1574-6968 | DOI: https://dx.doi.org/10.1111/j.1574-6968.2012.02567.x

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Abstract

Enterococcus faecalis exhibits high resistance to oxidative stress. Several enzymes are responsible for this trait. The role of alkyl hydroperoxide reductase (Ahp), thiol peroxidase (Tpx), and NADH peroxidase (Npr) in oxidative stress defense was recently characterized. Enterococcus faecalis, in contrast to many other streptococci, contains a catalase (KatA), but this enzyme can only be formed when the bacterium is supplied with heme. We have used this heme dependency of catalase activity and mutants deficient in KatA and Npr to investigate the role of the catalase in resistance against exogenous and endogenous hydrogen peroxide stress. The results demonstrate that in the presence of environmental heme catalase contributes to the protection against toxic effects of hydrogen peroxide.

Keywords: oxidative stress; heme; NADH peroxidase; streptococci

Journal Article.  2585 words.  Illustrated.

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