Journal Article

Ghrelin and Peptide YY Change During Puberty: Relationships With Adolescent Growth, Development, and Obesity

Hoi Lun Cheng, Amanda Sainsbury, Frances Garden, Myuran Sritharan, Karen Paxton, Georgina Luscombe, Catherine Hawke and Katharine Steinbeck

in The Journal of Clinical Endocrinology & Metabolism

Published on behalf of Endocrine Society

Volume 103, issue 8, pages 2851-2860
ISSN: 0021-972X
Published online May 2018 | e-ISSN: 1945-7197 | DOI: https://dx.doi.org/10.1210/jc.2017-01825
Ghrelin and Peptide YY Change During Puberty: Relationships With Adolescent Growth, Development, and Obesity

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  • Medicine and Health
  • Clinical Medicine
  • Endocrinology and Diabetes
  • Medical Oncology
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Abstract

Context

Pubertal adolescents show strong appetites. How this is mediated is unclear, but ghrelin and peptide YY (PYY) play potentially important roles.

Objective

To measure ghrelin and PYY change in relation to pubertal growth.

Design

Three-year prospective cohort study.

Setting

Australian regional community.

Participants

Eighty healthy adolescents (26 girls; 54 boys) recruited at 10 to 13 years.

Main Outcome Measures

Fasting circulating total ghrelin, total PYY, IGF-1, insulin, leptin (via radioimmunoassay), estradiol and testosterone (via mass spectrometry), anthropometry, and body composition (via bioelectrical impedance).

Results

Adolescents exhibited normal developmental change. Mixed models revealed positive associations for ghrelin to age2 (both sexes: P < 0.05), indicating a U-shaped trend over time. Ghrelin was also inversely associated with IGF-1 (both sexes: P < 0.05), leptin in girls (P < 0.01), and insulin in boys (P < 0.05) and negatively correlated with annual height and weight velocity (both sexes: P ≤ 0.01). PYY showed no age-related change in either sex. Neither ghrelin nor PYY were associated with Tanner stage. Weight subgroup analyses showed significant ghrelin associations with age2 in healthy-weight but not overweight and obese adolescents (7 girls; 18 boys).

Conclusions

Adolescents showed a U-shaped change in ghrelin corresponding to physical and biochemical markers of growth, and no change in PYY. The overweight and obesity subgroup exhibited an apparent loss of the U-shaped ghrelin trend, but this finding may be attributed to greater maturity and its clinical significance is unclear. Further research on weight-related ghrelin and PYY trends at puberty is needed to understand how these peptides influence growth and long-term metabolic risk.

Journal Article.  6523 words.  Illustrated.

Subjects: Medicine and Health ; Clinical Medicine ; Endocrinology and Diabetes ; Medical Oncology ; Reproductive Medicine

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