Journal Article

Association of A1538G and C2437T Single Nucleotide Polymorphisms in Heat Shock Protein 70 Genes with Type 2 Diabetes

Dhamodharan Umapathy, Ezhilarasi Krishnamoorthy, Parthiban Muthukumaran, Rama Rajaram, Indira Padmalayam and Vijay Viswanathan

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 43, issue 6, pages 250-255
Published in print November 2012 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI: https://dx.doi.org/10.1309/LM1LE9TNGIJFD7PS
Association of A1538G and C2437T Single Nucleotide Polymorphisms in Heat Shock Protein 70 Genes with Type 2 Diabetes

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  • Clinical Cytogenetics and Molecular Genetics
  • Chemistry
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

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Objective

To examine 2 single nucleotide polymorphisms (SNPs) of the heat shock protein 70-2 (HSPA1B) and 70-hom (HSPA1L) genes in patients with type 2 diabetes mellitus (T2DM) in our study population.

Methods

A total of 104 patients with T2DM and 124 healthy control individuals were included in the study. G1538A in HSPA1B and C2437T in HSPA1L polymorphisms were determined using the polymerase chain reaction–restriction fragment length polymorphism technique.

Results

The frequency of the HSPA1B genotype was as follows: AA: 33 (26.6%); AG: 82 (66.2%); and GG: 9 (7.2%) in the control group and AA: 2 (2.0%), AG: 57 (54.8%), and GG: 45 (43.2%) in the T2DM group (P<.001). The frequency of the HSPA1L genotype was as follows: CC: 20 (16.1%), CT: 92 (74.2%), and TT: 12 (9.7%) in the control group and CC: 8 (7.6%), CT: 65 (62.5%), and TT: 31 (29.8%) in the T2DM group (P = .003).

Conclusion

Our findings indicate that HSPA1B, HSPA1L, and their functional polymorphisms may play a role in the pathogenesis of T2DM.

Keywords: HSP; polymorphism; single nucleotide; type 2 diabetes

Journal Article.  3109 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics ; Chemistry ; Molecular and Cell Biology ; Molecular Biology and Genetics

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