Journal Article

Association of a Polymorphism Within Intron 8 But Not Exon 9 of the Vitamin D Receptor in Patients With Multiple Sclerosis of Southeastern Iranian Ethnicity

Reza Mosavi, Mohammad Kazemi Arababadi, Gholamhossein Hassanshahi, Hossein Azin, Majid Araste, Vajihe Akbarpour Salehabad, Reza Vazirinejad, Reza Pourali, Hamid Hakimi and Derek Kennedy

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 44, issue 3, pages 215-219
Published in print August 2013 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI: https://dx.doi.org/10.1309/LM8GLJHWING18CLB
Association of a Polymorphism Within Intron 8 But Not Exon 9 of the Vitamin D Receptor in Patients With Multiple Sclerosis of Southeastern Iranian Ethnicity

More Like This

Show all results sharing these subjects:

  • Clinical Cytogenetics and Molecular Genetics
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

GO

Show Summary Details

Preview

Objective:

To investigate the association between multiple sclerosis (MS) and polymorphisms in intron 8 and exon 9 of the vitamin D receptor (VDR) gene.

Methods:

Blood samples were collected from 100 patients with MS and 100 healthy control individuals in ethylenediaminetetraacetic acid (EDTA) tubes. DNA was extracted and analyzed via polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for polymorphisms within the VDR. Demographic data were also collected via a questionnaire designed specifically for this study.

Results:

Our results showed a significant difference between the A/A genotype and between the A and a alleles of intron 8 of VDR ; however, no differences were observed in the other studied alleles.

Conclusion:

VDR and its functional polymorphisms may be associated with MS.

Keywords: multiple sclerosis; vitamin D receptor; polymorphism

Journal Article.  2520 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics ; Molecular and Cell Biology ; Molecular Biology and Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.