Journal Article

Late Relapse of Acute Promyelocytic Leukemia: Literature Review and Results of Seven Years of Clinical and Laboratory Follow-Up of a Korean Patient

Min Jin Kim, Sun Young Cho, Hee Joo Lee, Jin-Tae Suh, Woo-In Lee, Juhie Lee, Sun Kyung Baek, Hwi-Joong Yoon and Tae Sung Park

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 43, issue 5, pages 205-211
Published in print August 2012 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI: https://dx.doi.org/10.1309/LMRAS7OLKUXPUO4G
Late Relapse of Acute Promyelocytic Leukemia: Literature Review and Results of Seven Years of Clinical and Laboratory Follow-Up of a Korean Patient

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  • Haematology
  • Clinical Cytogenetics and Molecular Genetics
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

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Among patients with acute promyelocytic leukemia (APL), 10% to 30% experience relapse. Most relapses occur within 2 years; only a few, known as late relapses, occur 4 years after achievement of the first complete remission (CR). We present a rare case of an ethnic Asian patient with APL who experienced late relapse, which has been continuously monitored by reverse transcription polymerase chain reaction (RT-PCR) for long-term molecular remission. Recently, the European APL Group published 2 large-scale studies related to late-relapse APL; however, only 2 Asian cases of late-relapse APL had previously been documented in the literature. We consider this case to be the first report of a patient with late-relapse APL in South Korea and believe that future studies of late-relapse APL for Asian and other ethnic groups are necessary.

Keywords: late relapse; acute promyelocytic leukemia; favorable prognosis; Asian

Journal Article.  2326 words.  Illustrated.

Subjects: Haematology ; Clinical Cytogenetics and Molecular Genetics ; Molecular and Cell Biology ; Molecular Biology and Genetics

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