Journal Article

Association of Serum YKL-40 With the Presence and Severity of Obstructive Sleep Apnea Syndrome

Wei Li, Zhen Yu and Chengcheng Jiang

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 45, issue 3, pages 220-225
Published in print August 2014 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI: https://dx.doi.org/10.1309/LMS98AKCXRSL2XOR
Association of Serum YKL-40 With the Presence and Severity of Obstructive Sleep Apnea Syndrome

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  • Clinical Cytogenetics and Molecular Genetics
  • Chemistry
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

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Objective:

This study examined the association of serum YKL-40 concentrations with the presence and severity of obstructive sleep apnea syndrome (OSAS).

Methods:

A total of 156 patients with OSAS and 110 healthy subjects were enrolled in this study.

Results:

OSAS patients had significantly higher serum YKL-40 levels compared with healthy controls. Multivariable logistic regression analysis indicated that serum YKL-40 levels were an independent determinant of the presence of OSAS. Serum YKL-40 levels were significantly elevated in severe OSAS patients compared with mild and moderate OSAS patients. Spearman correlation analysis revealed that serum YKL-40 levels were correlated with the severity of OSAS. Simple linear regression analysis showed that the serum levels of YKL-40 were correlated with body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein (CRP), and apnea-hypopnea index (AHI) in patients with OSAS.

Conclusion:

Elevated serum YKL-40 levels are associated with the presence and severity of OSAS.

Keywords: YKL-40; inflammation; obstructive sleep apnea syndrome; severity

Journal Article.  2786 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics ; Chemistry ; Molecular and Cell Biology ; Molecular Biology and Genetics

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