Journal Article

Cytokine Gene Polymorphisms and Viral Hepatitis Infections in Kidney Transplant Recipients

Mohammad Hossein Karimi, Ramin Yaghobi, Khadijeh Arjmandi, Bita Geramizadeh, Saman Nikeghbalian and Seyed Ali Malekhosseini

in Laboratory Medicine

Published on behalf of American Society for Clinical Pathology

Volume 44, issue 2, pages 114-120
Published in print May 2013 | ISSN: 0007-5027
Published online September 2015 | e-ISSN: 1943-7730 | DOI: https://dx.doi.org/10.1309/LMSHLD2N8MOLBO1N
Cytokine Gene Polymorphisms and Viral Hepatitis Infections in Kidney Transplant Recipients

More Like This

Show all results sharing these subjects:

  • Clinical Cytogenetics and Molecular Genetics
  • Chemistry
  • Molecular and Cell Biology
  • Molecular Biology and Genetics

GO

Show Summary Details

Preview

Objectives:

To examine the prevalence and role of cytokine gene polymorphism in susceptibility to viral hepatitis infections among kidney transplant recipients.

Methods:

The genetic polymorphisms of interleukin 6 (IL-6) G-174C, transforming growth factor beta (TGF-β) T+869C, interleukin 4 (IL-4) C-590T, and interferon gamma (IFN-γ) T+874A cytokines from 100 kidney transplant recipients were evaluated by amplification refractory mutation system–polymerase chain reaction (ARMS-PCR) and polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) methods.

Results:

The IFN-γ +874 TT genotype (P =.02) significantly correlated with hepatitis C virus (HCV) infection in kidney transplant recipients.

The IL-6 +174 GG genotype (P =.01) was significantly associated with acute rejection in kidney transplant recipients without HCV infection. A significant relationship to the IFN-γ +874 AA genotype (P =.04) was observed in kidney transplant recipients who did not experience transplant rejection and who are not infected with HBV. Also, a significant relationship was detected between the IL-6 and174 GC genotypes (P =.03) with nonacute rejection in kidney transplant recipients.

Conclusion:

We confirm a significant association between the cytokine genetic polymorphisms discussed herein. This information could be helpful toward better prediction of acute kidney rejection with or without viral hepatitis infections.

Keywords: hepatitis viruses; cytokine gene polymorphism; kidney transplantation

Journal Article.  2488 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics ; Chemistry ; Molecular and Cell Biology ; Molecular Biology and Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.