Journal Article

In vitro activity of aminosterols against dermatophytes

Oumar Coulibaly, Kamel Alhanout, Coralie L'Ollivier, Jean-Michel Brunel, Mahamadou A Thera, Abdoulaye A Djimdé, Ogobara K Doumbo, Renaud Piarroux and Stéphane Ranque

in Medical Mycology

Published on behalf of International Society for Human and Animal Mycology

Volume 51, issue 3, pages 309-312
Published in print April 2013 | ISSN: 1369-3786
Published online April 2013 | e-ISSN: 1460-2709 | DOI: https://dx.doi.org/10.3109/13693786.2012.724773
In vitro activity of aminosterols against dermatophytes

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  • Mycology and Fungi
  • Infectious Diseases
  • Medical Toxicology
  • Veterinary Medicine
  • Environmental Science

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We recently reported that aminosterols are fungicidal due to their disrupting the outer membranes of yeasts and that they have a significant in vitro activity against various mould species. Yet, their activity against dermatophytes had never been tested. This study’s objective was to evaluate the in vitro activity of squalamine and a synthetic aminosterol derivative (ASD) against various dermatophytes. Susceptibility testing of squalamine, ASD, terbinafine, and griseofulvin was performed, in triplicate, in accord with the Clinical Laboratory and Standards Institute’s M38-A2 procedure, using an 80% growth inhibition endpoint. The studies included the following dermatophytes: Trichophyton rubrum, T. mentagrophytes, T. soudanense, Microsporum canis, M. audouinii, M. persicolor; M. cookie and M. gypseum. Squalamine and ASD showed significant in vitro activity against these dermatophytes. The minimum inhibitory concentrations (MICs) ranged from 4–16 mg/l and from 2–8 mg/l for squalamine and ASD, respectively. These findings support further clinical studies of aminosterols activity against superficial dermatophyte infections.

Keywords: Squalamine; aminosterol synthetic derivate; antifungals; terbinafine; griseofulvin; CMI

Journal Article.  1759 words. 

Subjects: Mycology and Fungi ; Infectious Diseases ; Medical Toxicology ; Veterinary Medicine ; Environmental Science

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