Journal Article

Atypical velogenic Newcastle disease in a commercial layer flock in Japan

Dennis V. Umali, Hiroshi Ito, Kazutoshi Shirota, Toshihiro Ito and Hiromitsu Katoh

in Poultry Science

Volume 94, issue 5, pages 890-897
Published in print May 2015 | ISSN: 0032-5791
Published online March 2015 | e-ISSN: 1525-3171 | DOI: https://dx.doi.org/10.3382/ps/pev011
Atypical velogenic Newcastle disease in a commercial layer flock in Japan

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  • Zoology and Animal Sciences
  • Animal Pathology and Diseases
  • Animal Physiology
  • Ornithology
  • Veterinary Medicine

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In 2002, a commercial layer flock in Japan was initially diagnosed as being infected with infectious bronchitis (IB) based on clinical signs, virus isolation, and serological analysis but was later found to be atypically infected with velogenic Newcastle disease virus (NDV) following molecular diagnosis. The flock had slightly decreased egg production and an increased occurrence of soft-shelled eggs without significant mortality. IB-like viruses were isolated, which caused dwarfing and curling in 12-day-old chicken embryos. Ten years after this case, retrospective genetic analyses showed that apart from IB virus (IBV), the flock was also infected with NDV. Mean death time (MDT), intracerebral pathogenicity index (ICPI), and deduced amino acid sequence of the cleavage site of the fusion (F)-protein gene revealed that the NDV isolate was velogenic (112RRQKR116). These results indicate that poultry clinicians should look out for atypical velogenic ND, especially in vaccinated commercial chicken flocks, which may harbor hidden NDV infection.

Keywords: commercial layer flock; avian infectious bronchitis; silent infection; velogenic Newcastle disease

Journal Article.  3295 words.  Illustrated.

Subjects: Zoology and Animal Sciences ; Animal Pathology and Diseases ; Animal Physiology ; Ornithology ; Veterinary Medicine

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