Journal Article

Genotypic and pathotypic characterization of Newcastle disease virus isolated from racing pigeons in China

Mengda Liu, Yajin Qu, Fangkun Wang, Sidang Liu and Honglei Sun

in Poultry Science

Volume 94, issue 7, pages 1476-1482
Published in print July 2015 | ISSN: 0032-5791
Published online April 2015 | e-ISSN: 1525-3171 | DOI: https://dx.doi.org/10.3382/ps/pev106
Genotypic and pathotypic characterization of Newcastle disease virus isolated from racing pigeons in China

More Like This

Show all results sharing these subjects:

  • Zoology and Animal Sciences
  • Animal Pathology and Diseases
  • Animal Physiology
  • Ornithology
  • Veterinary Medicine

GO

Show Summary Details

Preview

A Newcastle disease virus (NDV) isolated from an outbreak in racing pigeons in China was characterized in this study. Complete gene of the NDV isolate was sequenced and phylogenetic analysis. Pathogenicity experiment was carried out in pigeons, chickens, and ducks. Phylogenetic analysis revealed that the strain clustered with the Class II viruses, has highly phylogenetically similar to NDV strains isolated from pigeons in China, but was distant from the viruses prevalence in chickens and vaccine strains used in China. The deduced amino acid sequence of the cleavage site of the fusion (F) protein confirmed that the isolate contained the virulent motif 112RRQKRF117 at the cleavage site, but it caused no appearance disease in chickens and ducks. However, the isolate had virulence in pigeons, resulting in severe nervous signs and highly mortality. Pigeons were considered as a potential source of NDV infection and disease for commercial poultry flocks. Therefore, new vaccines to prevent the NDV infection in the pigeon flocks should be developed as soon as possible, and strict biosecurity measures should be taken to reduce the risk of pigeon Newcastle disease outbreaks.

Keywords: Newcastle disease virus; racing pigeon; phylogenetic analysis; pathology

Journal Article.  3319 words.  Illustrated.

Subjects: Zoology and Animal Sciences ; Animal Pathology and Diseases ; Animal Physiology ; Ornithology ; Veterinary Medicine

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content. subscribe or login to access all content.