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Carbon Ion Radiotherapy: Clinical Experiences at National Institute of Radiological Science (NIRS)

Tohru Okada, Tadashi Kamada, Hiroshi Tsuji, Jun-etsu Mizoe, Masayuki Baba, Shingo Kato, Shigeru Yamada, Shinji Sugahara, Shigeo Yasuda, Naoyoshi Yamamoto, Reiko Imai, Azusa Hasegawa, Hiroshi Imada, Hiroki Kiyohara, Kenichi Jingu, Makoto Shinoto and Hirohiko Tsujii.

in Journal of Radiation Research

July 2010; p ublished online May 2010 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

In June 1994, the world's first clinical center offering carbon ion radiotherapy opened at the National Institute of Radiological Science (NIRS), Japan. Among several types of ion species,...

Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation

Yuya Yoshimoto, Takahiro Oike, Noriyuki Okonogi, Yoshiyuki Suzuki, Ken Ando, Hiro Sato, Shin-ei Noda, Mayu Isono, Kousaku Mimura, Koji Kono and Takashi Nakano.

in Journal of Radiation Research

May 2015; p ublished online March 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 2950 words.

X-ray radiotherapy activates tumor antigen-specific T-cell responses, and increases in the serum levels of high mobility group box 1 (HMGB1) induced by X-ray irradiation play a pivotal role...

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Carbon-ion pencil beam scanning for thoracic treatment – initiation report and dose metrics evaluation

Masataka Karube, Shinichiro Mori, Hiroshi Tsuji, Naoyoshi Yamamoto, Mio Nakajima, Keiichi Nakagawa and Tadashi Kamada.

in Journal of Radiation Research

September 2016; p ublished online September 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 3983 words.

Carbon-ion beam scanning has not previously been used for moving tumor treatments. We have commenced respiratory-gated carbon-ion radiotherapy (CIRT) in the thoracic and abdominal regions...

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Carbon-ion radiotherapy for inoperable endometrial carcinoma

Daisuke Irie, Noriyuki Okonogi, Masaru Wakatsuki, Shingo Kato, Tatsuya Ohno, Kumiko Karasawa, Hiroki Kiyohara, Daijiro Kobayashi, Hiroshi Tsuji, Takashi Nakano, Tadashi Kamada and Makio Shozu.

in Journal of Radiation Research

May 2018; p ublished online March 2018 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4448 words.

Abstract

This is a pooled analysis to evaluate the toxicity and efficacy of carbon-ion radiotherapy (C-ion RT) for inoperable endometrial carcinoma. Eligible...

Carbon-ion radiotherapy for patients with advanced stage non–small-cell lung cancer at multicenters

Masataka Karube, Naoyoshi Yamamoto, Yoshiyuki Shioyama, Junichi Saito, Akira Matsunobu, Tamaki Okimoto, Tatsuya Ohno, Hiroshi Tsuji, Takashi Nakano and Tadashi Kamada.

in Journal of Radiation Research

September 2017; p ublished online July 2017 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 2105 words.

ABSTRACT

Carbon-ion radiation therapy (CIRT) for advanced non–small-cell lung cancer (NSCLC) has not been well studied to date. This paper aimed to analyze a...

Caudal epidural anesthesia during intracavitary brachytherapy for cervical cancer

Yuko Isoyama-Shirakawa, Katsumasa Nakamura, Madoka Abe, Naonobu Kunitake, Keiji Matsumoto, Saiji Ohga, Tomonari Sasaki, Satoru Uehara, Kazuhiro Okushima, Yoshiyuki Shioyama and Hiroshi Honda.

in Journal of Radiation Research

May 2015; p ublished online April 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 3037 words.

It has been suggested that pain control during intracavitary brachytherapy for cervical cancer is insufficient in most hospitals in Japan. Our hospital began using caudal epidural...

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Cell Cycle Perturbations and Genotoxic Effects in Human Primary Fibroblasts Induced by Low-energy Protons and X/γ-rays

Antonio Antoccia, Antonella Sgura, Francesco Berardinelli, Maria Cavinato, Roberto Cherubini, Silvia Gerardi and Caterina Tanzarella.

in Journal of Radiation Research

September 2009; p ublished online September 2009 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 0 words.

The effect of graded doses of high-linear energy transfer (LET) low-energy protons to induce cycle perturbations and genotoxic damage was investigated in normal human fibroblasts....

Cell-permeable intrinsic cellular inhibitors of apoptosis protect and rescue intestinal epithelial cells from radiation-induced cell death

Shiori Matsuzaki-Horibuchi, Takeshi Yasuda, Nagako Sakaguchi, Yoshihiro Yamaguchi and Makoto Akashi.

in Journal of Radiation Research

January 2015; p ublished online October 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 7031 words.

One of the important mechanisms for gastrointestinal (GI) injury following high-dose radiation exposure is apoptosis of epithelial cells. X-linked inhibitor of apoptosis (XIAP) and cellular...

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Changes in the distribution and function of leukocytes after whole-body iron ion irradiation

Daila S. Gridley and Michael J. Pecaut.

in Journal of Radiation Research

September 2016; p ublished online September 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 6979 words.

High-energy particle radiation could have a considerable impact on health during space missions. This study evaluated C57BL/6 mice on Day 40 after total-body 56Fe26+ irradiation at 0, 1, 2...

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Characteristics of human CD34+ cells exposed to ionizing radiation under cytokine-free conditions

Junya Ishikawa, Naoki Hayashi, Masaru Yamaguchi, Satoru Monzen and Ikuo Kashiwakura.

in Journal of Radiation Research

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 6387 words.

To clarify the mechanisms underlying radiation-induced hematopoietic stem cell death, we investigated the effects of excessive ionizing radiation on the clonogenic potential of CD34+ cells...

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Characterization of an orthovoltage biological irradiator used for radiobiological research

Rezvan Azimi, Parham Alaei, Emiliano Spezi and Susanta K. Hui.

in Journal of Radiation Research

May 2015; p ublished online February 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4836 words.

Orthovoltage irradiators are routinely used to irradiate specimens and small animals in biological research. There are several reports on the characteristics of these units for small field...

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Characterization of relative biological effectiveness for conventional radiation therapy: a comparison of clinical 6 MV X-rays and 137Cs

Michelle Howard, Chris Beltran, Jann Sarkaria and Michael G Herman.

in Journal of Radiation Research

September 2017; p ublished online April 2017 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 3205 words.

ABSTRACT

Various types of radiation are utilized in the treatment of cancer. Equal physical doses of different radiation types do not always result in the same...

Chemical repair activity of free radical scavenger edaravone: reduction reactions with dGMP hydroxyl radical adducts and suppression of base lesions and AP sites on irradiated plasmid DNA

Kuniki Hata, Ayumi Urushibara, Shinichi Yamashita, Mingzhang Lin, Yusa Muroya, Naoya Shikazono, Akinari Yokoya, Haiying Fu and Yosuke Katsumura.

in Journal of Radiation Research

January 2015; p ublished online September 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4461 words.

Reactions of edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one) with deoxyguanosine monophosphate (dGMP) hydroxyl radical adducts were investigated by pulse radiolysis technique. Edaravone was...

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Chromatin-regulating proteins as targets for cancer therapy

Takahiro Oike, Hideaki Ogiwara, Napapat Amornwichet, Takashi Nakano and Takashi Kohno.

in Journal of Radiation Research

July 2014; p ublished online February 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 8324 words.

Chromatin-regulating proteins represent a large class of novel targets for cancer therapy. In the context of radiotherapy, acetylation and deacetylation of histones by histone...

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Chronic low-dose γ-irradiation of Drosophila melanogaster larvae induces gene expression changes and enhances locomotive behavior

Cha Soon Kim, Ki Moon Seong, Byung Sub Lee, In Kyung Lee, Kwang Hee Yang, Ji-Young Kim and Seon Young Nam.

in Journal of Radiation Research

May 2015; p ublished online March 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4942 words.

Although radiation effects have been extensively studied, the biological effects of low-dose radiation (LDR) are controversial. This study investigates LDR-induced alterations in locomotive...

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Classification of radiation effects for dose limitation purposes: history, current situation and future prospects

Nobuyuki Hamada and Yuki Fujimichi.

in Journal of Radiation Research

July 2014; p ublished online May 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 8239 words.

Radiation exposure causes cancer and non-cancer health effects, each of which differs greatly in the shape of the dose–response curve, latency, persistency, recurrence, curability, fatality...

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Clinical applications of stereotactic radiation therapy for oligometastatic cancer patients: a disease-oriented approach

Umberto Ricardi, Serena Badellino and Andrea Riccardo Filippi.

in Journal of Radiation Research

August 2016; p ublished online August 2016 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 7356 words.

Oligometastases from solid tumors are currently recognized as a distinct clinical entity, corresponding to an intermediate state between local and widespread disease. It has been suggested...

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Clinical experience of volumetric modulated arc therapy for malignant pleural mesothelioma after extrapleural pneumonectomy

Tomoki Kimura, Yoshiko Doi, Takeo Nakashima, Nobuki Imano, Tsuyoshi Katsuta, Shigeo Takahashi, Masahiro Kenjo, Shuichi Ozawa, Yuji Murakami and Yasushi Nagata.

in Journal of Radiation Research

March 2015; p ublished online January 2015 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 4658 words.

The purpose of this study was to evaluate the efficacy and safety of volumetric modulated arc therapy (VMAT) after extrapleural pneumonectomy (EPP) in patients with malignant pleural...

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The clinical outcome of intracranial hemangioblastomas treated with linac-based stereotactic radiosurgery and radiotherapy

Putipun Puataweepong, Mantana Dhanachai, Ake Hansasuta, Somjai Dangprasert, Chomporn Sitathanee, Parmon Puddhikarant, Chuleeporn Jiarpinitnun, Rawee Ruangkanchanasetr, Patchareporn Dechsupa and Kumutinee Pairat.

in Journal of Radiation Research

July 2014; p ublished online February 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 3561 words.

Recent publications have reported stereotactic radiosurgery as an effective and safe treatment for intracranial hemangioblastomas. However, because of the low incidence of these particular...

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Clinical oxygen enhancement ratio of tumors in carbon ion radiotherapy: the influence of local oxygenation changes

Laura Antonovic, Emely Lindblom, Alexandru Dasu, Niels Bassler, Yoshiya Furusawa and Iuliana Toma-Dasu.

in Journal of Radiation Research

September 2014; p ublished online April 2014 .

Journal Article. Subjects: Clinical Genetics; Molecular Biology and Genetics; Epidemiology; Radiology; Nuclear Chemistry, Photochemistry, and Radiation. 5252 words.

The effect of carbon ion radiotherapy on hypoxic tumors has recently been questioned because of low linear energy transfer (LET) values in the spread-out Bragg peak (SOBP). The aim of this...

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