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Neurology x Clinical Pharmacology and Therapeutics x clear all

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Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients

Annamaria Cattaneo, Clarissa Ferrari, Rudolf Uher, Luisella Bocchio-Chiavetto, Marco Andrea Riva and Carmine M. Pariante.

in International Journal of Neuropsychopharmacology

P ublished online May 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8487 words.

Background:

Increased levels of inflammation have been associated with a poorer response to antidepressants in several clinical samples, but these findings...

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Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner

Jieun Kim, In Soo Ryu, Su Yeon Seo and Eun Sang Choe.

in International Journal of Neuropsychopharmacology

November 2015; p ublished online July 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 5785 words.

Background:

Phosphorylation state of dopamine- and cAMP-regulated phosphoprotein, molecular weight 32kDa (DARPP32) is crucial to understand drug-mediated...

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Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans

Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo and Michael A Nitsche.

in International Journal of Neuropsychopharmacology

P ublished online April 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6836 words.

Abstract

Background

Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in...

Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing

André Schmidt, Felix Müller, Patrick C Dolder, Yasmin Schmid, Davide Zanchi, Laura Egloff, Matthias E Liechti and Stefan Borgwardt.

in International Journal of Neuropsychopharmacology

P ublished online December 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7819 words.

Abstract

Background

Stimulants such as methylphenidate and modafinil are frequently used as cognitive enhancers in...

Acute Morphine Exposure Increases the Brain Distribution of [18F]DPA-714, a PET Biomarker of Glial Activation in Nonhuman Primates

Sylvain Auvity, Wadad Saba, Sébastien Goutal, Claire Leroy, Irène Buvat, Jérôme Cayla, Fabien Caillé, Michel Bottlaender, Salvatore Cisternino and Nicolas Tournier.

in International Journal of Neuropsychopharmacology

P ublished online August 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3121 words.

Abstract

Background:

The neuroinflammatory response to morphine exposure modulates its antinociceptive effects,...

Adolescent Alcohol Exposure-Induced Changes in Alpha-Melanocyte Stimulating Hormone and Neuropeptide Y Pathways via Histone Acetylation in the Brain During Adulthood

Dadasaheb M Kokare, Evan J Kyzar, Huaibo Zhang, Amul J Sakharkar and Subhash C Pandey.

in International Journal of Neuropsychopharmacology

P ublished online May 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7433 words.

Abstract

Background

Adolescent intermittent ethanol exposure causes long-lasting alterations in brain epigenetic...

Adolescent Synthetic Cannabinoid Exposure Produces Enduring Changes in Dopamine Neuron Activity in a Rodent Model of Schizophrenia Susceptibility

David D Aguilar, Andrea Giuffrida and Daniel J Lodge.

in International Journal of Neuropsychopharmacology

P ublished online January 2018 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8288 words.

Abstract

Background

Epidemiological studies recognize cannabis intake as a risk factor for schizophrenia, yet the...

Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling

Bruna Cuccurazzu, Erica Zamberletti, Cristiano Nazzaro, Pamela Prini, Massimo Trusel, Mariagrazia Grilli, Daniela Parolaro, Raffaella Tonini and Tiziana Rubino.

in International Journal of Neuropsychopharmacology

P ublished online June 2018 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7554 words.

Abstract

Background

In rodent models, chronic exposure to cannabis’ psychoactive ingredient, Δ9-tetrahydrocannabino...

Affinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia

Manabu Kubota, Tomohisa Nagashima, Harumasa Takano, Fumitoshi Kodaka, Hironobu Fujiwara, Keisuke Takahata, Sho Moriguchi, Yasuyuki Kimura, Makoto Higuchi, Yoshiro Okubo, Hidehiko Takahashi, Hiroshi Ito and Tetsuya Suhara.

in International Journal of Neuropsychopharmacology

P ublished online July 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 4890 words.

Abstract

Background

Dopamine D2 receptors are reported to have high-affinity (D2High) and low-affinity (D2Low)...

Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms

Giovanni Martinotti, Mauro Pettorruso, Domenico De Berardis, Paola Annunziata Varasano, Gabriella Lucidi Pressanti, Valeria De Remigis, Alessandro Valchera, Valerio Ricci, Marco Di Nicola, Luigi Janiri, Giovanni Biggio and Massimo Di Giannantonio.

in International Journal of Neuropsychopharmacology

P ublished online January 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 3604 words.

Background:

Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has...

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