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Biochemistry x Science and Mathematics x Enzymology x Bioinformatics and Computational Biology x clear all

The C-terminal region of translesion synthesis DNA polymerase η is partially unstructured and has high conformational flexibility

Kyle T Powers, Adrian H Elcock and M Todd Washington.

in Nucleic Acids Research

February 2018; p ublished online January 2018 .

Journal Article. Subjects: Enzymology; Molecular Biology and Genetics; Bioinformatics and Computational Biology. 9555 words.

Abstract

Eukaryotic DNA polymerase η catalyzes translesion synthesis of thymine dimers and 8-oxoguanines. It is comprised of a polymerase domain and a...

Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase

Zhong Ren.

in Nucleic Acids Research

September 2016; p ublished online June 2016 .

Journal Article. Subjects: Enzymology; Molecular Biology and Genetics; Bioinformatics and Computational Biology. 12316 words.

DNA polymerases in family B are workhorses of DNA replication that carry out the bulk of the job at a high speed with high accuracy. A polymerase in this family relies on a built-in...

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