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A high-throughput assay for Tn5 Tnp-induced DNA cleavage

Brandon Ason and William S. Reznikoff.

in Nucleic Acids Research

January 2004; p ublished online January 2004 .

Journal Article. Subjects: Enzymology; Molecular and Cell Biology; Molecular Biology and Genetics. 3431 words.

Transposition causes genomic instability by mobilizing DNA elements. This phenomenon is mechanistically related to other DNA rearrangements, such as V(D)J recombination and retroviral DNA...

Identification of human telomerase assembly inhibitors enabled by a novel method to produce hTERT

Guillaume Kellermann, Markus Kaiser, Florent Dingli, Olivier Lahuna, Delphine Naud-Martin, Florence Mahuteau-Betzer, Damarys Loew, Evelyne Ségal-Bendirdjian, Marie-Paule Teulade-Fichou and Sophie Bombard.

in Nucleic Acids Research

September 2015; p ublished online May 2015 .

Journal Article. Subjects: Proteins; Enzymology; Molecular and Cell Biology; Molecular Biology and Genetics. 7197 words.

Telomerase is the enzyme that maintains the length of telomeres. It is minimally constituted of two components: a core reverse transcriptase protein (hTERT) and an RNA (hTR). Despite its...

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