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Clinical Medicine x Clinical Pharmacology and Therapeutics x clear all

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abciximab

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

The Fab fragments of a monoclonal antibody directed against the glycoprotein IIb/IIIa receptor on platelets that blocks platelet aggregation. Used as a short-term treatment to prevent...

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Absolute Measurements of Macrophage Migration Inhibitory Factor and Interleukin-1-β mRNA Levels Accurately Predict Treatment Response in Depressed Patients

Annamaria Cattaneo, Clarissa Ferrari, Rudolf Uher, Luisella Bocchio-Chiavetto, Marco Andrea Riva and Carmine M. Pariante.

in International Journal of Neuropsychopharmacology

P ublished online May 2016 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 8487 words.

Background:

Increased levels of inflammation have been associated with a poorer response to antidepressants in several clinical samples, but these findings...

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acamprosate calcium

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A drug used, in conjunction with counselling, for the maintenance of sobriety. Patients must already be abstinent at the beginning of treatment. It is administered orally; the most common...

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acarbose

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

(ass-ar-bohz)

an oral hypoglycaemic drug that reduces the breakdown and absorption of carbohydrates in the intestine by blocking the action of an important enzyme (α-glucosidase)...

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ACE inhibitor

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

(ayss)

angiotensin-converting enzyme inhibitor: any one of a group of drugs used in the treatment of raised blood pressure and heart failure. ACE inhibitors act by interfering with...

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ACE inhibitors

Roy S. Gardner, Theresa A. McDonagh and Niki L. Walker.

in Heart Failure

August 2014; p ublished online August 2014 .

Chapter. Subjects: Cardiovascular Medicine; Clinical Pharmacology and Therapeutics. 1419 words.

ACE inhibitors were first introduced because of their vasodilatory properties. It is now understood that the beneficial effects arise from the antagonism of the...

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acebutolol

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

(ass-i-bew-toh-lol)

a beta blocker drug used to treat high blood pressure, angina pectoris, and irregular heart rhythms. It is administered by mouth. Trade name: Sectral.

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Acetaminophen

Chitra Ramasubbu and Anita Gupta.

in Pharmacology in Anesthesia Practice

January 2013; p ublished online September 2013 .

Chapter. Subjects: Anaesthetics; Clinical Pharmacology and Therapeutics. 1257 words.

This chapter discusses acetaminophen, including Clinical Uses /Relevance to Anesthesiology, Pharmacodynamics, Pharmacokinetics, Side Effects/Adverse Reactions, and Dosages/Preparation.

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acetazolamide

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, benign intracranial hypertension, altitude sickness, cystinuria, and dural ectasia. TN Diamox.

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Acetylcholine

Leslie L. Iversen, Susan D. Iversen, Floyd E. Bloom and Robert H. Roth.

in Introduction to Neuropsychopharmacology

January 2009; p ublished online September 2013 .

Chapter. Subjects: Clinical Pharmacology and Therapeutics; Pharmacology. 6695 words.

The neurophysiological activity of acetylcholine (ACh) has been known since the early 19th century and its neurotransmitter role since the mid-1920s. With this long history, it is not...

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Acetylcysteine

Shannon Bianchi and Anita Gupta.

in Pharmacology in Anesthesia Practice

January 2013; p ublished online September 2013 .

Chapter. Subjects: Anaesthetics; Clinical Pharmacology and Therapeutics. 1033 words.

This chapter discusses Acetylcysteine, including Role in the Practice of Anesthesiology/Relevance to Anesthesiology, Pharmacodynamics, Pharmacokinetics, Side Effects/Adverse Reactions, and...

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acetylcysteine

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

(ass-i-tyl-sis-ti-een)

a drug that is administered as eye drops for the treatment of dry eyes, as in Sjögren's syndrome; as an intravenous infusion, it is used to prevent liver...

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aciclovir

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A nucleoside analogue (hydroxyethoxymethylguanine) with antiviral properties against both type 1 and 2 herpes virus and varicella-zoster virus. The drug is converted to the monophosphate by...

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acipimox

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

A niacin derivative used to lower levels of cholesterol and other lipids in the blood by preventing the release of fatty acids from fatty tissue. TN Olbetam.

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acrivastine

Overview page. Subjects: Clinical Pharmacology and Therapeutics.

An antihistamine drug that acts on the histamine H1 receptor, used to treat allergies and hay fever.

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activated charcoal

Overview page. Subjects: Clinical Pharmacology and Therapeutics — Public Health and Epidemiology.

A preparation of charcoal that can adsorb toxicants, e.g., narcotics, chlorine gas. It is used in water filtration devices to remove organic chemical contaminants from drinking water and as...

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Activation of Protein Kinases and Phosphatases Coupled to Glutamate Receptors Regulates the Phosphorylation State of DARPP32 at Threonine 75 After Repeated Exposure to Cocaine in the Rat Dorsal Striatum in a Ca2+-Dependent Manner

Jieun Kim, In Soo Ryu, Su Yeon Seo and Eun Sang Choe.

in International Journal of Neuropsychopharmacology

November 2015; p ublished online July 2015 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 5785 words.

Background:

Phosphorylation state of dopamine- and cAMP-regulated phosphoprotein, molecular weight 32kDa (DARPP32) is crucial to understand drug-mediated...

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Active myocyte shortening during the ‘isovolumetric relaxation’ phase of diastole is responsible for ventricular suction; ‘systolic ventricular filling’

Gerald D. Buckberg, Manuel CastellÁ, Morteza Gharib and Saleh Saleh.

in European Journal of Cardio-Thoracic Surgery

April 2006; p ublished online April 2006 .

Journal Article. Subjects: Anatomy; Clinical Pharmacology and Therapeutics; Cardiovascular Medicine. 6212 words.

Objective: To study the ‘isovolumetric relaxation’ phase of rapid ventricular filling by analysis of the shortening of cardiac muscle in the endocardial and epicardial segments...

Acute and Chronic Noradrenergic Effects on Cortical Excitability in Healthy Humans

Hsiao-I Kuo, Walter Paulus, Giorgi Batsikadze, Asif Jamil, Min-Fang Kuo and Michael A Nitsche.

in International Journal of Neuropsychopharmacology

P ublished online April 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 6836 words.

Abstract

Background

Noradrenaline is a major neuromodulator in the central nervous system, and it is involved in...

Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing

André Schmidt, Felix Müller, Patrick C Dolder, Yasmin Schmid, Davide Zanchi, Laura Egloff, Matthias E Liechti and Stefan Borgwardt.

in International Journal of Neuropsychopharmacology

P ublished online December 2017 .

Journal Article. Subjects: Clinical Pharmacology and Therapeutics; Neurology; Psychiatry; Neuroscience. 7819 words.

Abstract

Background

Stimulants such as methylphenidate and modafinil are frequently used as cognitive enhancers in...