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Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice

Lowenna J Holt, Amanda E Brandon, Lewin Small, Eurwin Suryana, Elaine Preston, Donna Wilks, Nancy Mokbel, Chantal A Coles, Jason D White, Nigel Turner, Roger J Daly and Gregory J Cooney.

in Endocrinology

P ublished online January 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 6668 words.

Abstract

Grb10 is an adaptor-type signaling protein most highly expressed in tissues involved in insulin action and glucose metabolism, such as muscle,...

The Absence of Laminin α4 in Male Mice Results in Enhanced Energy Expenditure and Increased Beige Subcutaneous Adipose Tissue

Marcella K Vaicik, Alen Blagajcevic, Honggang Ye, Mallory C Morse, Feipeng Yang, Anna Goddi, Eric M Brey and Ronald N Cohen.

in Endocrinology

P ublished online July 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8016 words.

Abstract

Laminin α4 (LAMA4) is located in the extracellular basement membrane that surrounds each individual adipocyte. Here we show that LAMA4 null (Lama4−/−null...

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ACC2 Deletion Enhances IMCL Reduction Along With Acetyl-CoA Metabolism and Improves Insulin Sensitivity in Male Mice

Hiroyuki Takagi, Tatsuya Ikehara, Yuto Kashiwagi, Kumi Hashimoto, Isamu Nanchi, Atsuyuki Shimazaki, Hirohide Nambu and Hideo Yukioka.

in Endocrinology

P ublished online June 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 8054 words.

Abstract

Intramyocellular lipid (IMCL) accumulation in skeletal muscle greatly contributes to lipid-induced insulin resistance. Because acetyl-coenzyme A (CoA)...

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Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice

Marie-José Lecomte, Chloé Bertolus, Nélina Ramanantsoa, Françoise Saurini, Jacques Callebert, Catherine Sénamaud-Beaufort, Maud Ringot, Thomas Bourgeois, Boris Matrot, Corinne Collet, Jeannette Nardelli, Jacques Mallet, Guilan Vodjdani, Jorge Gallego, Jean-Marie Launay and Sylvie Berrard.

in Endocrinology

P ublished online March 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 10764 words.

Abstract

Pituitary growth hormone (GH) and insulinlike growth factor (IGF)-1 are anabolic hormones whose physiological roles are particularly important during...

Acromegaly

John A. H. Wass, Peter J. Trainer and Márta Korbonits.

in Oxford Textbook of Endocrinology and Diabetes

July 2011; p ublished online July 2011 .

Chapter. Subjects: Endocrinology and Diabetes. 8800 words.

Acromegaly is the condition most often associated with an anterior pituitary tumour, which results from growth hormone and insulin-like growth factor 1 (IGF-1) excess. It causes most...

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Activation of the Mineralocorticoid Receptor Increases Striatin Levels

Luminita H. Pojoga, Patricia Coutinho, Alicia Rivera, Tham M. Yao, Enrique R. Maldonado, Rodeler Youte, Gail K. Adler, Jonathan Williams, Alexander Turchin, Gordon H. Williams and Jose R. Romero.

in American Journal of Hypertension

February 2012; p ublished online February 2012 .

Journal Article. Subjects: Neuroendocrinology and Autonomic Nervous System; Biochemistry; Endocrinology and Diabetes. 5033 words.

Background:

Aldosterone (ALDO), a critical regulator of sodium homeostasis, mediates its effects via activation of the mineralocorticoid receptor (MR)...

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ACTIVExtend: 24 Months of Alendronate After 18 Months of Abaloparatide or Placebo for Postmenopausal Osteoporosis

Henry G Bone, Felicia Cosman, Paul D Miller, Gregory C Williams, Gary Hattersley, Ming-yi Hu, Lorraine A Fitzpatrick, Bruce Mitlak, Socrates Papapoulos, René Rizzoli, Robin K Dore, John P Bilezikian and Kenneth G Saag.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online May 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5356 words.

Abstract

Purpose

In women with postmenopausal osteoporosis, we investigated the effects of 24 months of treatment...

Acute adrenal insufficiency as a first presentation of myelodysplastic syndrome and sigmoid colon adenocarcinoma: a case report

Angeliki Kleanthous, Elena Koushiappi, Yiolanda Herodotou, Elena Xenofontos and Emmelia Vounou.

in Oxford Medical Case Reports

P ublished online August 2014 .

Journal Article. Subjects: Medicine and Health; Endocrinology and Diabetes. 1414 words.

Acute adrenal failure due to bilateral adrenal haemorrhage is rare and may initially present with non-specific symptoms. It can rapidly progress into a life-threatening condition if not...

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Acute complications of diabetes

Edited by Lorraine Avery and Sue Beckwith.

in Oxford Handbook of Diabetes Nursing

P ublished online August 2010 .

Chapter. Subjects: Endocrinology and Diabetes. 3308 words.

Hypoglycaemia: overview and symptoms - Hypoglycaemia: causes - Hypoglycaemia: treatment and consequences - Hyperglycaemia - Intercurrent illness and infections - Diabetic ketoacidosis -...

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Addition of Estradiol to Cross-Sex Testosterone Therapy Reduces Atherosclerosis Plaque Formation in Female ApoE−/− Mice

Laura G Goetz, Ramanaiah Mamillapalli, Cagdas Sahin, Masoumeh Majidi-Zolbin, Guanghao Ge, Arya Mani and Hugh S Taylor.

in Endocrinology

P ublished online December 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 7060 words.

Abstract

The contributions of estradiol and testosterone to atherosclerotic lesion progression are not entirely understood. Cross-sex hormone therapy (XHT) for...

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Adipocyte Expression of SLC19A1 Links DNA Hypermethylation to Adipose Tissue Inflammation and Insulin Resistance

Paul Petrus, Lucia Bialesova, Antonio Checa, Alastair Kerr, Shama Naz, Jesper Bäckdahl, Ana Gracia, Sofia Toft, Karin Dahlman-Wright, Per Hedén, Ingrid Dahlman, Craig E Wheelock, Peter Arner, Niklas Mejhert, Hui Gao and Mikael Rydén.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online November 2017 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 7412 words.

Abstract

Context

Insulin resistance (IR) is promoted by a chronic low-grade inflammation in white adipose tissue...

Adipose Tissue Inflammation and Adrenomedullin Overexpression Contribute to Lipid Dysregulation in Diabetic Pregnancies

Yuanlin Dong, Madhu Chauhan, Ancizar Betancourt, Michael Belfort and Chandra Yallampalli.

in The Journal of Clinical Endocrinology & Metabolism

P ublished online July 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 5866 words.

Abstract

Context

Impaired maternal lipid metabolism in gestational diabetes mellitus (GDM) has detrimental effects...

Adolescence and emerging adulthood

David Levy.

in Type 1 Diabetes

P ublished online September 2011 .

Chapter. Subjects: Endocrinology and Diabetes. 6772 words.

• During puberty and adolescence there are profound changes in endocrinology, especially in the growth hormone axis, but their contribution to vascular complications is still not clear. •...

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Adolescence and emerging adulthood

David Levy.

in Type 1 Diabetes

July 2016; p ublished online September 2016 .

Chapter. Subjects: Clinical Medicine; Endocrinology and Diabetes. 6964 words.

Adolescence and emerging childhood forms an increasing proportion of the lifespan of urbanized individuals. Glycaemic control worsens during adolescence; physiology and psychology...

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Adrenal

John Wass, Katharine Owen and Helen Turner.

in Oxford Handbook of Endocrinology and Diabetes

April 2014; p ublished online March 2014 .

Chapter. Subjects: Endocrinology and Diabetes. 14412 words.

Anatomy - Physiology - Imaging - Mineralocorticoid excess: definitions - Primary aldosteronism - Conn’s syndrome—aldosterone-producing adenoma - Bilateral adrenal hyperplasia (bilateral...

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The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms

William C Engeland, Logan Massman, Shubhendu Mishra, J Marina Yoder, Sining Leng, Emanuele Pignatti, Mary E Piper, Diana L Carlone, David T Breault and Paulo Kofuji.

in Endocrinology

P ublished online October 2018 .

Journal Article. Subjects: Medicine and Health; Clinical Medicine; Endocrinology and Diabetes; Medical Oncology; Reproductive Medicine. 10207 words.

Abstract

The glucocorticoid (GC) rhythm is entrained to light-dark (LD) cycles via a molecular clock in the suprachiasmatic nucleus (SCN) and is maintained by...

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Adrenal gland

Helen E. Turner, Richard Eastell and Ashley Grossman.

in Oxford Desk Reference: Endocrinology

June 2018; p ublished online August 2018 .

Chapter. Subjects: Endocrinology and Diabetes. 43029 words.

This chapter describes the adrenal gland’s structure and disorders. The adrenal gland is a vital mediator of an organism’s response to stress, and is a critical regulator of immune...

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Adrenal gland disorders

Gary Butler and Jeremy Kirk.

in Paediatric Endocrinology and Diabetes

May 2011; p ublished online October 2011 .

Chapter. Subjects: Endocrinology and Diabetes; Paediatrics. 2701 words.

Physiology 236

Adrenal insufficiency 238

Adrenal steroid excess 246

Further reading 247

null...

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Adrenal imaging

Peter Guest.

in Oxford Textbook of Endocrinology and Diabetes

July 2011; p ublished online July 2011 .

Chapter. Subjects: Endocrinology and Diabetes. 6058 words.

Evaluating the adrenal gland with imaging can be challenging. The adrenal glands may be morphologically within normal limits even in the presence of clear hyperfunction. Hyperplasia and...

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Adrenal incidentaloma

Massimo Terzolo.

in Oxford Textbook of Endocrinology and Diabetes

July 2011; p ublished online July 2011 .

Chapter. Subjects: Endocrinology and Diabetes. 6954 words.

Adrenal incidentaloma is an adrenal mass that is discovered serendipitously with a radiological examination performed for indications unrelated to adrenal disease (1). The incidental...

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