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Adaptive T-cell immunity and tumor antigen recognition

Pedro Romero and Pierre G Coulie.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 5684 words.

Current advances in cancer immunotherapy are based on the antigenicity of human tumors, and also on their immunogenicity. Their antigenicity results from the presence at the cell surface of...

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Adoptive lymphocyte (stem cell) therapy in cancer

Sophie Derniame and Aurore Saudemont.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6065 words.

Haematopoietic stem cell transplantation (HSCT) is the infusion of haematopoietic stem cells and progenitor cells to restore a patient’s haematopoiesis. With more than 40 years of research...

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Adoptive T-cell therapy using TILs for the treatment of metastatic melanoma

Marco Donia, Eva Ellebæk and Inge Marie Svane.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6836 words.

Adoptive T-cell therapy (ACT) with tumor-infiltrating lymphocytes (TILs or TIL-based ACT) is a personalized treatment for cancer defined as the infusion of T cells isolated from the...

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Antibody therapies: defining appropriate cell surface epitopes for targeting tumors

Gabriele Multhoff and Michael Stanglmaier.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6280 words.

Numerous tumor mouse models have clearly shown that an active immune system can monitor, edit and destroy malignantly transformed cells. However, the capacity of the immune system to fight...

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Cancer stem cells (CSCs) and epithelial-to-mesenchymal transition (EMT): Tumor cell plasticity challenges immunotherapy

Tarik Regad and Morgan G Mathieu.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 5887 words.

Cancer stem cells (CSCs) or cancer-initiating cells are populations of cancer cells that possess the stem cell properties of self-renewal and differentiation and therefore behave as their...

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Chambers, Helen (1879–1935), pathologist and cancer research worker

Peter D. Mohr.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Medicine and Health; Pathology; Medical Oncology; Radiation Oncology; Surgical Oncology. 1235 words.

Chambers, Helen (1879–1935), pathologist and cancer research worker, was born on 18 July 1879 in Bombay, India, the only daughter of Frederick Chambers, of the Indian Civil Service. Her...

Chimeric antigen receptor gene therapy in cancer

John S Bridgeman and David E Gilham.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6056 words.

T cells are a major effector arm of the adaptive immune system and possess the potential to eliminate tumors. However, this potential is blunted in the cancer-bearing patient as a result of...

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Controversies in the Management of Salivary Gland Disease

Edited by Mark McGurk and James Graham Combes.

November 2012; p ublished online May 2013 .

Book. Subjects: Surgery; Histopathology; Epidemiology; Oral and Maxillofacial Surgery; Anaesthetics; Surgical Skills; Paediatrics; Medical Oncology; Surgical Oncology; Clinical Radiology; Clinical Pharmacology and Therapeutics. 376 pages.

Addressing controversial and topical issues in the field of salivary gland disease and surgical management of salivary gland disease, this new edition integrates the newest clinical...

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DNA vaccines

Lindy G Durrant, Wei Xue, Lee R Machado, Rachael L Metheringham and Victoria A Brentville.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6604 words.

A number of significant developments in DNA vaccine research have led to the resurgence of this field as a promising approach for the treatment of cancer. Notably, these include improved...

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Endovascular Treatment of Fast-flow Vascular Anomalies

Patricia E. Burrows.

in Mulliken and Young's Vascular Anomalies

August 2013; p ublished online November 2013 .

Chapter. Subjects: Surgery; Histopathology; Interventional Radiology. 20836 words.

Chapter 20 describes and illustrates embolization techniques and outcomes for a variety of fast-flow vascular malformations from simple arteriovenous fistulas (AVF) to extensive AVMs....

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FRCS Trauma and Orthopaedics Viva

Nev Davies, Will Jackson, Andrew Price, Jonathan Rees and Chris Lavy.

July 2012; p ublished online May 2013 .

Book. Subjects: Trauma and Orthopaedic Surgery; Professional Development in Medicine; Pathology; Rheumatology; Infectious Diseases; Clinical Radiology; Paediatrics; Histopathology; Surgical Skills; Endocrinology and Diabetes; Haematology; Medical Statistics and Methodology. 224 pages.

FRCS Trauma and Orthopaedics Viva offers a unique approach to this high stakes exam, from the team behind the highly successful Oxford revision course. Based on the principle that viva...

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Haddow, Sir Alexander (1907–1976), experimental pathologist in cancer research

D. A. G. Galton.

in Oxford Dictionary of National Biography

September 2004; p ublished online September 2004 .

Reference Entry. Subjects: Medicine and Health; Pathology; Medical Oncology; Radiation Oncology; Surgical Oncology. 1305 words.

Haddow, Sir Alexander (1907–1976), experimental pathologist in cancer research, was born on 18 January 1907, at Leven, Fife, Scotland, the elder son of William Haddow (1864–1928), miner,...

‘Hard’ and ‘soft’ loss of MHC class I expression in cancer cells

Natalia Aptsiauri, Angel M. Garcia-Lora and Federico Garrido.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 7043 words.

Altered MHC class I expression is a hallmark of malignant transformation and tumor immune escape. Using immunohistochemistry and molecular techniques it has been demonstrated that many...

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Heart Failure

Roy S. Gardner, Theresa A. McDonagh and Niki L. Walker.

August 2014; p ublished online August 2014 .

Book. Subjects: Cardiovascular Medicine; Pathology; Clinical Skills; Complementary and Alternative Medicine; Clinical Pharmacology and Therapeutics; Cardiothoracic Surgery; Interventional Radiology; Surgical Skills; Transplant Surgery; Critical Care; Medical Oncology; Endocrinology and Diabetes; Respiratory Medicine and Pulmonology; Medical Skills; Peri-operative Care; Palliative Medicine. 512 pages.

Heart failure is an important and ever expanding sub-speciality of cardiology, and many health care professional bodies are now developing specialist expertise in heart failure. With...

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HER2/neu as a target for vaccine and antibody-directed therapies

Constantin N Baxevanis and Sonia A Perez.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 7488 words.

A novel modality toward the treatment of HER2/neu-positive malignancies, mostly including breast and, more recently, prostate carcinomas, has been the use of vaccines targeting HER2/neu...

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Identification of tumor antigens for clinical evaluation

Jayakumar Vadakekolathu, Amanda K Miles, David J Boocock and Stephanie EB McArdle.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 5511 words.

The idea of the immune system being able to fight cancerous cells was first put forward during the 18th century when German doctors observed that infected tumors would often shrink...

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Immune escape and ageing of the immune system compromises the immune response to tumor antigens

Ludmila Müller and Graham Pawelec.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6858 words.

Ageing is an important risk factor for most solid cancers. Once commonly viewed as a consequence of the multi-hit theory of carcinogenesis requiring the accumulation of many mutations over...

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Immune-checkpoint blockade in cancer immunotherapy

Patrick A Ott and F Stephen Hodi.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6191 words.

Monoclonal antibodies directed against checkpoint molecules such as CTLA-4, B7-H1, and PD-1 have recently demonstrated remarkable therapeutic activity in patients with melanoma, renal cell...

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Impact of ageing and body mass on cancer immunotherapy outcomes

Gail D Sckisel, Arta M Monjazeb, Annie Mirsoian, Anthony E Zamora, Steven Grossenbacher and William J Murphy.

in Tumor Immunology and Immunotherapy

May 2014; p ublished online July 2014 .

Chapter. Subjects: Immunology; Radiation Oncology. 6375 words.

Cancer is a devastating disease, affecting up to one in two individuals over the course of their lifespan. The majority of first-line therapies are cytotoxic in nature, but recent advances...

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Kay, Humphrey Edward Melville (1923–2009), haematologist and oncologist

Alex May.

in Oxford Dictionary of National Biography

P ublished online January 2013 .

Reference Entry. Subjects: Medical Oncology; Radiation Oncology; Surgical Oncology; Haematology; Pathology. 949 words.

Kay, Humphrey Edward Melville (1923–2009), haematologist and oncologist, was born on 10 October 1923 at 19 Spencer Road, Croydon, Surrey, the son of the Revd Arnold Innes Kay (1888–1945), a...