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Acceleration of nucleation of prion protein during continuous ultrasonication

Kei-ichi Yamaguchi, Ryo P Honda, Abdelazim Elsayed Elhelaly and Kazuo Kuwata.

in The Journal of Biochemistry

June 2018; p ublished online February 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6445 words.

Abstract

Although pulsatile irradiation of ultrasonication is frequently used for generating amyloid fibrils in vitro, the potential for inducing amyloid...

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Activity-dependent functions of non-electrical glial cells

Daisuke Kato, Kei Eto, Junichi Nabekura and Hiroaki Wake.

in The Journal of Biochemistry

June 2018; p ublished online February 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 4884 words.

Abstract

Electrical activity is essential for brain function. However, neurons, the electrically active cells, are less numerous than the non-electrical glial...

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Adiponectin suppression of late inflammatory mediator, HMGB1-induced cytokine expression in RAW264 macrophage cells

Mohamed Elfeky, Takeshi Yoneshiro, Yuko Okamatsu-Ogura and Kazuhiro Kimura.

in The Journal of Biochemistry

February 2018; p ublished online October 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 5939 words.

Abstract

High-mobility group protein B1 (HMGB1) is a late inflammatory mediator released from inflammatory cells when stimulated, resulting in exaggerating...

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Amino acid sequence analysis and characterization of a ribonuclease from starfish Asterias amurensis

Naomi Motoyoshi, Hiroko Kobayashi, Tadashi Itagaki and Norio Inokuchi.

in The Journal of Biochemistry

September 2016; p ublished online February 2016 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 5114 words.

The aim of this study was to phylogenetically characterize the location of the RNase T2 enzyme in the starfish (Asterias amurensis). We isolated an RNase T2 ribonuclease (RNase Aa) from the...

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5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside stimulates the rat enhancer of split- and hairy-related protein-2 gene via atypical protein kinase C lambda

Yoshiko Komatsu, Yuki Yanagisawa, Maya Moriizumi, Yuuki Tsuchiya, Honami Yokouchi, Hatsumi Otsuka, Mizuki Aoyagi, Akiko Tsukada, Yukiko Kanai, Ayumi Haneishi, Katsuhiro Takagi, Kosuke Asano, Moe Ono, Takashi Tanaka, Koji Tomita and Kazuya Yamada.

in The Journal of Biochemistry

April 2016; p ublished online November 2015 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 4678 words.

The 5′-AMP-activated protein kinase (AMPK) functions as a cellular energy sensor. 5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside (AICAR) is a chemical activator of AMPK. In the liver,...

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Analysis of novel Sir3 binding regions in Saccharomyces cerevisiae

Risa Mitsumori, Tomoe Ohashi, Kazuto Kugou, Ayako Ichino, Kei Taniguchi, Kunihiro Ohta, Hiroyuki Uchida and Masaya Oki.

in The Journal of Biochemistry

July 2016; p ublished online March 2016 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 3629 words.

In Saccharomyces cerevisiae, the HMR, HML, telomere and rDNA regions are silenced. Silencing at the rDNA region requires Sir2, and silencing at the HMR, HML and telomere regions requires...

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Antioxidants as stabilizers for His6-OPH: is this an unusual or regular role for them with enzymes?

Elena N Efremenko, Ilya V Lyagin, Le H Cuong and Le M Huong.

in The Journal of Biochemistry

November 2017; p ublished online June 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 4542 words.

Abstract

The effect of 14 different antioxidants on the activity of a hexahistidine-tagged organophosphorus hydrolase (His6-OPH) has been studied in vitro. It...

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Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking

Hideki Yamamoto, Akira Sato and Akira Kikuchi.

in The Journal of Biochemistry

November 2017; p ublished online July 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6343 words.

Abstract

Wnts are glycosylated proteins secreted from various cell types including mesenchymal, hematopoietic and epithelial cells. Directional secretion of...

Apical-to-basolateral transepithelial transport of cow’s milk caseins by intestinal Caco-2 cell monolayers: MS-based quantitation of cellularly degraded α- and β-casein fragments

Nao Sakurai, Shunsuke Nishio, Yuka Akiyama, Shinji Miyata, Kenzi Oshima, Daita Nadano and Tsukasa Matsuda.

in The Journal of Biochemistry

August 2018; p ublished online February 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 7621 words.

Abstract

Casein (CN) is the major milk protein to nourish infants but, in certain population, it causes cow’s milk allergy, indicating the uptake of antigenic...

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Aptamers that bind specifically to human KPNA2 (importin-α1) and efficiently interfere with nuclear transport

Noriko Yasuhara and Penmetcha K.R. Kumar.

in The Journal of Biochemistry

November 2016; p ublished online May 2016 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 5948 words.

The importin-α family of proteins plays an important role in the eukaryotic importin/exportin nuclear transport system. These proteins recognize a nuclear localization signal (NLS) within...

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The assembly mechanism of coiled-coil domains of the yeast cargo receptors Emp46p/47p and the mutational alteration of pH-dependency of complex formation

Koichi Kato, Takahisa Furuhashi, Koichi Kato, Akifumi Oda and Eiji Kurimoto.

in The Journal of Biochemistry

May 2018; p ublished online January 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 3161 words.

Abstract

The coiled-coil domains of the putative yeast cargo receptors Emp46p and Emp47p are responsible for their complex-formation in the Endoplasmic...

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Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection

Daisuke Fujikura, Daisuke Muramatsu, Kochi Toyomane, Satoko Chiba, Takuji Daito, Atsushi Iwai, Takahisa Kouwaki, Masaaki Okamoto, Hideaki Higashi, Hiroshi Kida and Hiroyuki Oshiumi.

in The Journal of Biochemistry

January 2018; p ublished online October 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 4309 words.

Abstract

Several microbial molecules with pathogen-associated molecular patterns stimulate host innate immune responses. The innate immune system plays a...

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Azide anions inhibit GH-18 endochitinase and GH-20 Exo β-N-acetylglucosaminidase from the marine bacterium Vibrio harveyi

Paknisa Sirimontree, Tamo Fukamizo and Wipa Suginta.

in The Journal of Biochemistry

February 2016; p ublished online September 2015 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6269 words.

Vibrio harveyi is a bioluminescent marine bacterium that utilizes chitin as its sole source of energy. In the course of chitin degradation, the bacterium primarily secretes an...

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Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners

Takashi Muramatsu.

in The Journal of Biochemistry

May 2016; p ublished online December 2015 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6019 words.

Basigin, also called CD147 or EMMPRIN, is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. Basigin has isoforms; the common form (basigin or basigin-2) has two...

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Biological functions of sulfoglycolipids and the EMARS method for identification of co-clustered molecules in the membrane microdomains

Koichi Honke.

in The Journal of Biochemistry

April 2018; p ublished online November 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 7326 words.

Abstract

Two major sulfoglycolipids, sulfatide (SO3-3Gal-ceramide) and seminolipid (SO3-3Gal-alkylacylglycerol) exist in mammals. Sulfatide is abundant in the...

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Biophysical studies on calcium and carbohydrate binding to carbohydrate recognition domain of Gal/GalNAc lectin from Entamoeba histolytica: insights into host cell adhesion

Rupali Yadav, Kuldeep Verma, Mintu Chandra, Madhumita Mukherjee and Sunando Datta.

in The Journal of Biochemistry

September 2016; p ublished online March 2016 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6263 words.

Entamoeba histolytica, an enteric parasite expresses a Gal/GalNAc-specific lectin that contributes to its virulence by establishing adhesion to host cell. In this study,...

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Ca2+/calmodulin-dependent protein kinase II promotes neurodegeneration caused by tau phosphorylated at Ser262/356 in a transgenic Drosophila model of tauopathy

Mikiko Oka, Naoki Fujisaki, Akiko Maruko-Otake, Yosuke Ohtake, Sawako Shimizu, Taro Saito, Shin-Ichi Hisanaga, Koichi M Iijima and Kanae Ando.

in The Journal of Biochemistry

November 2017; p ublished online June 2017 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 3951 words.

Abstract

Abnormal deposition of the microtubule-associated protein tau is a common pathological feature of multiple neurodegenerative diseases, including...

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Capsid protease domain as a tool for assessing protein-domain folding during organelle import of nascent polypeptides in living cells

Kongsoo Kang, Michiyo Takahara, Haruka Sakaue and Masao Sakaguchi.

in The Journal of Biochemistry

May 2016; p ublished online December 2015 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 6521 words.

Various proteins synthesized by ribosomes are imported into specific organelles. To elucidate the behavior of protein domains during import, we developed a folding probe, in which the...

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CD169 macrophages regulate immune responses toward particulate materials in the circulating fluid

Kenichi Asano, Kenta Kikuchi and Masato Tanaka.

in The Journal of Biochemistry

August 2018; p ublished online June 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 5786 words.

Abstract

Tissue macrophages comprise heterogeneous subsets that differ in localization, phenotype and ontogeny. They acquire tissue-specific phenotype in order...

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Cell surface chondroitin sulphate proteoglycan 4 (CSPG4) binds to the basement membrane heparan sulphate proteoglycan, perlecan, and is involved in cell adhesion

Fengying Tang, Megan S Lord, William B Stallcup and John M Whitelock.

in The Journal of Biochemistry

May 2018; p ublished online February 2018 .

Journal Article. Subjects: Cell Biology; Biotechnology; Biochemistry; Molecular and Cell Biology. 9524 words.

Abstract

Chondroitin sulphate proteoglycan 4 (CSPG4) is a cell surface proteoglycan highly expressed by tumour, perivascular and oligodendrocyte cells and...

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