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Neuropathology x clear all

Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment

Alex I Wiesman, Jennifer O’Neill, Mackenzie S Mills, Kevin R Robertson, Howard S Fox, Susan Swindells and Tony W Wilson.

in Brain

June 2018; p ublished online April 2018 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 7877 words.

Abstract

Combination antiretroviral therapies have revolutionized the treatment of HIV infection, and many patients now enjoy a lifespan equal to that of the...

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Abnormalities of fixation, saccade and pursuit in posterior cortical atrophy

Timothy J. Shakespeare, Diego Kaski, Keir X. X. Yong, Ross W. Paterson, Catherine F. Slattery, Natalie S. Ryan, Jonathan M. Schott and Sebastian J. Crutch.

in Brain

July 2015; p ublished online April 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 9780 words.

The clinico-neuroradiological syndrome posterior cortical atrophy is the cardinal ‘visual dementia’ and most common atypical Alzheimer’s disease phenotype, offering insights into mechanisms...

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Accumulation of murine amyloid-β mimics early Alzheimer’s disease

Markus Krohn, Alexander Bracke, Yosef Avchalumov, Toni Schumacher, Jacqueline Hofrichter, Kristin Paarmann, Christina Fröhlich, Cathleen Lange, Thomas Brüning, Oliver von Bohlen und Halbach and Jens Pahnke.

in Brain

August 2015; p ublished online May 2015 .

Journal Article. Subjects: Disorders of the Nervous System; Neuropathology. 7267 words.

Amyloidosis mouse models of Alzheimer’s disease are generally established by transgenic approaches leading to an overexpression of mutated human genes that are known to be involved in the...

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Active role of capillary pericytes during stimulation-induced activity and spreading depolarization

Lila Khennouf, Bodil Gesslein, Alexey Brazhe, J Christopher Octeau, Nikolay Kutuzov, Baljit S Khakh and Martin Lauritzen.

in Brain

July 2018; p ublished online June 2018 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System; Pain Medicine. 8636 words.

Abstract

Spreading depolarization is assumed to be the mechanism of migraine with aura, which is accompanied by an initial predominant hyperaemic response...

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Allogeneic haematopoietic stem cell transplantation for mitochondrial neurogastrointestinal encephalomyopathy

Joerg P. Halter, W. Michael, M. Schüpbach, Hanna Mandel, Carlo Casali, Kim Orchard, Matthew Collin, David Valcarcel, Attilio Rovelli, Massimiliano Filosto, Maria T. Dotti, Giuseppe Marotta, Guillem Pintos, Pere Barba, Anna Accarino, Christelle Ferra, Isabel Illa, Yves Beguin, Jaap A. Bakker, Jaap J. Boelens, Irenaeus F. M. de Coo, Keith Fay, Carolyn M. Sue, David Nachbaur, Heinz Zoller, Claudia Sobreira, Belinda Pinto Simoes, Simon R. Hammans, David Savage, Ramon Martí, Patrick F. Chinnery, Ronit Elhasid, Alois Gratwohl and Michio Hirano.

in Brain

October 2015; p ublished online August 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 6101 words.

Haematopoietic stem cell transplantation has been proposed as treatment for mitochondrial neurogastrointestinal encephalomyopathy, a rare fatal autosomal recessive disease due to TYMP mutat...

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Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency

Dewei Jiang, Ying Zhang, Ronald P. Hart, Jianmin Chen, Karl Herrup and Jiali Li.

in Brain

December 2015; p ublished online October 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8858 words.

A long-standing mystery surrounding ataxia-telangiectasia is why it is mainly cerebellar neurons, Purkinje cells in particular, that appear vulnerable to ATM deficiency. Here we present...

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Alterations in the hypothalamic melanocortin pathway in amyotrophic lateral sclerosis

Pauline Vercruysse, Jérôme Sinniger, Hajer El Oussini, Jelena Scekic-Zahirovic, Stéphane Dieterlé, Reinhard Dengler, Thomas Meyer, Stephan Zierz, Jan Kassubek, Wilhelm Fischer, Jens Dreyhaupt, Torsten Grehl, Andreas Hermann, Julian Grosskreutz, Anke Witting, Ludo Van Den Bosch, Odile Spreux-Varoquaux, Albert C. Ludolph and Luc Dupuis.

in Brain

April 2016; p ublished online March 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 8567 words.

Amyotrophic lateral sclerosis, the most common adult-onset motor neuron disease, leads to death within 3 to 5 years after onset. Beyond progressive motor impairment, patients with...

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Altered caudate connectivity is associated with executive dysfunction after traumatic brain injury

Sara De Simoni, Peter O Jenkins, Niall J Bourke, Jessica J Fleminger, Peter J Hellyer, Amy E Jolly, Maneesh C Patel, James H Cole, Robert Leech and David J Sharp.

in Brain

January 2018; p ublished online November 2017 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 9554 words.

Abstract

Traumatic brain injury often produces executive dysfunction. This characteristic cognitive impairment often causes long-term problems with behaviour...

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Altered PDE10A expression detectable early before symptomatic onset in Huntington’s disease

Flavia Niccolini, Salman Haider, Tiago Reis Marques, Nils Muhlert, Andri C. Tziortzi, Graham E. Searle, Sridhar Natesan, Paola Piccini, Shitij Kapur, Eugenii A. Rabiner, Roger N. Gunn, Sarah J. Tabrizi and Marios Politis.

in Brain

October 2015; p ublished online July 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Disorders of the Nervous System; Neuropathology. 8891 words.

There is an urgent need for early biomarkers and novel disease-modifying therapies in Huntington’s disease. Huntington’s disease pathology involves the toxic effect of mutant huntingtin...

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Alzheimer’s disease cerebrospinal fluid biomarker in cognitively normal subjects

Jon B. Toledo, Henrik Zetterberg, Argonde C. van Harten, Lidia Glodzik, Pablo Martinez-Lage, Luisella Bocchio-Chiavetto, Lorena Rami, Oskar Hansson, Reisa Sperling, Sebastiaan Engelborghs, Ricardo S. Osorio, Hugo Vanderstichele, Manu Vandijck, Harald Hampel, Stefan Teipl, Abhay Moghekar, Marilyn Albert, William T. Hu, Jose A. Monge Argilés, Ana Gorostidi, Charlotte E. Teunissen, Peter P. De Deyn, Bradley T. Hyman, Jose L. Molinuevo, Giovanni B. Frisoni, Gurutz Linazasoro, Mony J. de Leon, Wiesje M. van der Flier, Philip Scheltens, Kaj Blennow, Leslie M. Shaw and John Q. Trojanowski.

in Brain

September 2015; p ublished online July 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 8402 words.

In a large multicentre sample of cognitively normal subjects, as a function of age, gender and APOE genotype, we studied the frequency of abnormal cerebrospinal fluid levels of Alzheimer’s...

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Alzheimer-related decrease in CYFIP2 links amyloid production to tau hyperphosphorylation and memory loss

Sachin Suresh Tiwari, Keiko Mizuno, Anshua Ghosh, Wajeeha Aziz, Claire Troakes, Jason Daoud, Vidushi Golash, Wendy Noble, Tibor Hortobágyi and Karl Peter Giese.

in Brain

October 2016; p ublished online August 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 9837 words.

Characteristic features of Alzheimer’s disease are memory loss, plaques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofibrillary tangles and...

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Amyloid-β deposition and regional grey matter atrophy rates in dementia with Lewy bodies

Lidia Sarro, Matthew L. Senjem, Emily S. Lundt, Scott A. Przybelski, Timothy G. Lesnick, Jonathan Graff-Radford, Bradley F. Boeve, Val J. Lowe, Tanis J. Ferman, David S. Knopman, Giancarlo Comi, Massimo Filippi, Ronald C. Petersen, Clifford R. Jack and Kejal Kantarci.

in Brain

October 2016; p ublished online July 2016 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 7011 words.

Alzheimer’s disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia...

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Amyloid-β dimers in the absence of plaque pathology impair learning and synaptic plasticity

Andreas Müller-Schiffmann, Arne Herring, Laila Abdel-Hafiz, Aisa N. Chepkova, Sandra Schäble, Diana Wedel, Anselm H. C. Horn, Heinrich Sticht, Maria A. de Souza Silva, Kurt Gottmann, Olga A. Sergeeva, Joseph P. Huston, Kathy Keyvani and Carsten Korth.

in Brain

February 2016; p ublished online December 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 11431 words.

Despite amyloid plaques, consisting of insoluble, aggregated amyloid-β peptides, being a defining feature of Alzheimer’s disease, their significance has been challenged due to controversial...

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Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs

Rajnish Kumar, Agneta Nordberg and Taher Darreh-Shori.

in Brain

January 2016; p ublished online November 2015 .

Journal Article. Subjects: Neuropathology; Disorders of the Nervous System. 12217 words.

Amyloid-β peptides, through highly sophisticated enzymatic machinery, are universally produced and released in an action potential synchronized manner into the interstitial fluids in the...

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Anti-ganglioside antibodies are removed from circulation in mice by neuronal endocytosis

Madeleine E. Cunningham, Rhona McGonigal, Gavin R. Meehan, Jennifer A. Barrie, Denggao Yao, Susan K. Halstead and Hugh J. Willison.

in Brain

June 2016; p ublished online March 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 4732 words.

See van Doorn and Jacobs (doi:10.1093/brain/aww078) for a scientific commentary on this article.  

In axonal forms of Guillain-Barré syndrome,...

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Anti-Jo-1 antibody-positive patients show a characteristic necrotizing perifascicular myositis

Lénaig Mescam-Mancini, Yves Allenbach, Baptiste Hervier, Hervé Devilliers, Kuberaka Mariampillay, Odile Dubourg, Thierry Maisonobe, Romain Gherardi, Paulette Mezin, Corinna Preusse, Werner Stenzel and Olivier Benveniste.

in Brain

September 2015; p ublished online July 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 3656 words.

Idiopathic inflammatory myopathies can be classified as polymyositis, dermatomyositis, immune-mediated necrotizing myopathy, sporadic inclusion body myositis or non-specific myositis....

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Anxiety and Depression

David L. Brody.

in Concussion Care Manual

May 2019; p ublished online April 2019 .

Chapter. Subjects: Neurology; Rehabilitation Medicine; Neuropathology. 1892 words.

First, assess safety. Severe anxiety and depression can lead to suicide. Second, distinguish between reactive anxiety and depressive symptoms vs. an impairing mood disorder. The ‘treatment’...

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Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson’s disease

Joseph J. Locascio, Shirley Eberly, Zhixiang Liao, Ganqiang Liu, Ashley N. Hoesing, Karen Duong, Ana Trisini-Lipsanopoulos, Kaltra Dhima, Albert Y. Hung, Alice W. Flaherty, Michael A. Schwarzschild, Michael T. Hayes, Anne-Marie Wills, U. Shivraj Sohur, Nicte I. Mejia, Dennis J. Selkoe, David Oakes, Ira Shoulson, Xianjun Dong, Ken Marek, Bin Zheng, Adrian Ivinson, Bradley T. Hyman, John H. Growdon, Lewis R. Sudarsky, Michael G. Schlossmacher, Bernard Ravina and Clemens R. Scherzer.

in Brain

September 2015; p ublished online July 2015 .

Journal Article. Subjects: Neuropathology; Sensory and Motor Systems; Disorders of the Nervous System. 8385 words.

There are no cures for neurodegenerative diseases and this is partially due to the difficulty of monitoring pathogenic molecules in patients during life. The Parkinson’s disease gene...

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Association of inclusion body myositis with T cell large granular lymphocytic leukaemia

Steven A. Greenberg, Jack L. Pinkus, Anthony A. Amato, Thomas Kristensen and David M. Dorfman.

in Brain

May 2016; p ublished online February 2016 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 5636 words.

See Hohlfeld and Schulze-Koops (doi:10.1093/brain/aww053) for a scientific commentary on this article.

Inclusion body myositis and T cell large granular...

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Astrocytic TYMP and VEGFA drive blood–brain barrier opening in inflammatory central nervous system lesions

Candice Chapouly, Azeb Tadesse Argaw, Sam Horng, Kamilah Castro, Jingya Zhang, Linnea Asp, Hannah Loo, Benjamin M. Laitman, John N. Mariani, Rebecca Straus Farber, Elena Zaslavsky, German Nudelman, Cedric S. Raine and Gareth R. John.

in Brain

June 2015; p ublished online March 2015 .

Journal Article. Subjects: Sensory and Motor Systems; Neuropathology; Disorders of the Nervous System. 11915 words.

In inflammatory central nervous system conditions such as multiple sclerosis, breakdown of the blood–brain barrier is a key event in lesion pathogenesis, predisposing to oedema,...

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